Evidence map›Paper›PMID 33643294›Full record

ArticleFrontiers in immunology2020

Mobilized Multipotent Hematopoietic Progenitors Promote Expansion and Survival of Allogeneic Tregs and Protect Against Graft Versus Host Disease.

Maud D'Aveni, Anne-Béatrice Notarantonio, Viviane A Agbogan, Allan Bertrand, Guillemette Fouquet, Pauline Gastineau, Meriem Garfa-Traoré, Marcelo De Carvalho, Olivier Hermine, Marie-Thérèse Rubio and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Maud D'AveniUniversité de Lorraine, CHRU Nancy, Hematology Department, Nancy, France.
Anne-Béatrice NotarantonioUniversité de Lorraine, CHRU Nancy, Hematology Department, Nancy, France.
Viviane A AgboganDepartment of Immunology, Infectiology and Haematology, Université de Paris, Inserm U1151, CNRS UMR 8253, Institut Necker Enfants Malades (INEM), Paris, France.
Allan BertrandUniversité de Lorraine, UMR 7365 CNRS, IMoPA, Nancy, France.
Guillemette FouquetUniversité de Paris, INSERM UMR 1163, Imagine Institute, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, Paris, France.
Pauline GastineauDepartment of Immunology, Infectiology and Haematology, Université de Paris, Inserm U1151, CNRS UMR 8253, Institut Necker Enfants Malades (INEM), Paris, France.
Meriem Garfa-TraoréUniversité de Paris, SFR Necker-UMS 3633/US24-Structure Fédérative de Recherche Necker, Plateforme d'Imagerie Cellulaire, Paris, France.
Marcelo De CarvalhoUniversité de Lorraine, UMR 7365 CNRS, IMoPA, Nancy, France.
Olivier HermineUniversité de Paris, INSERM UMR 1163, Imagine Institute, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, Paris, France.
Marie-Thérèse RubioUniversité de Lorraine, CHRU Nancy, Hematology Department, Nancy, France.
Flora ZavalaDepartment of Immunology, Infectiology and Haematology, Université de Paris, Inserm U1151, CNRS UMR 8253, Institut Necker Enfants Malades (INEM), Paris, France.
Centre National de la Recherche Scientifique · FRInserm · FRLaboratoire d’Imagerie Biomédicale · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) is routinely performed with peripheral blood stem cells (PBSCs) mobilized by injection of G-CSF, a growth factor which not only modulates normal hematopoiesis but also induces diverse immature regulatory cells. Based on our previous evidence that G-CSF-mobilized multipotent hematopoietic progenitors (MPP) can increase survival and proliferation of natural regulatory T cells (Tregs) in autoimmune disorders, we addressed the question how these cells come into play in mice and humans in an alloimmune setting. Using a C57BL/6 mouse model, we demonstrate that mobilized MPP enhance the immunosuppressant effect exerted by Tregs, against alloreactive T lymphocytes, both

Indexed as

Adoptive TransferCell ProliferationHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationLymphocyte ActivationAnimalsCells, CulturedCoculture TechniquesCytokinesDisease Models, AnimalGraft vs Host DiseaseHumansMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLCytokinesallogeneic HSCTalloreactivityexpansiongraft versus host diseasemixed lymphocyte reactionmobilizationmultipotent progenitorsregulatory T cells

Identifiers

PMID33643294
PMCPMC7907505
OpenAlexW3130531420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.