Evidence map›Paper›PMID 33643282›Full record

ArticleFrontiers in immunology2020

ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.

Viktor Bugajev, Ivana Halova, Livia Demkova, Sara Cernohouzova, Petra Vavrova, Michal Mrkacek, Pavol Utekal, Lubica Draberova, Ladislav Kuchar, Björn Schuster and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell-Type Dependent and Tied to Ceramide Homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Viktor BugajevDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Ivana HalovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Livia DemkovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Sara CernohouzovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Petra VavrovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Michal MrkacekDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Pavol UtekalDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Lubica DraberovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Ladislav KucharResearch Unit for Rare Diseases, Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Björn SchusterCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Petr DraberDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Czech Academy of Sciences, Institute of Molecular Genetics · CZGeneral University Hospital in Prague · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The systemic anaphylactic reaction is a life-threatening allergic response initiated by activated mast cells. Sphingolipids are an essential player in the development and attenuation of this response.

Indexed as

Signal TransductionAmino Acid SequenceAnaphylaxisAnimalsBiomarkersCalciumCalcium SignalingChemotaxisCytokinesDisease SusceptibilityGene ExpressionLysophospholipidsMast CellsMembrane ProteinsMiceMice, KnockoutBiomarkersCalciumCytokinesLysophospholipidsMembrane ProteinsORMDL3 protein, mouseSphingolipidsSphingosinesphingosine 1-phosphateFcϵRImast cellsORMDL familypassive cutaneous anaphylactic reactionpassive systemic anaphylaxissphingolipidssphingosine-1-phosphate

Identifiers

PMID33643282
PMCPMC7905224
OpenAlexW3127900639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.