ArticleFrontiers in physiology2021
The Role of Long-Term Head-Down Bed Rest in Understanding Inter-Individual Variation in Response to the Spaceflight Environment: A Perspective Review.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Introducing the Concept of Exercise Holidays for Human Spaceflight - What Can We Learn From the Recovery of Bed Rest Passive Control Groups.Frontiers in physiology · 2022Pooled it
- NEX4EX - A novel exercise device enabling resistive, plyometric and sensorimotor training during deep-space missions: A case report.Experimental physiology · 2026Article
- Comparison of musculoskeletal responses and its variability after long-term spaceflight and prolonged bed rest conditions.NPJ microgravity · 2026Article
- Network physiology in space: vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on earth.Frontiers in network physiology · 2026Article
- AI-based prediction of VONPJ microgravity · 2025Article
- Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system.NPJ microgravity · 2025Review
- Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Variability in individual musculoskeletal response is not increased by countermeasures during bed rest.Frontiers in physiology · 2025Article
- From astronauts to stroke survivors: how the TheraSuit Method® can boost balance and recovery.Frontiers in neurology · 2025Article
- Space Analogs and Behavioral Health Performance Research review and recommendations checklist from ESA Topical Team.NPJ microgravity · 2024Review
- Acute cardiovascular and muscular response to rowing ergometer exercise in artificial gravity - a pilot trial.NPJ microgravity · 2024Article
- Myths and Methodologies: Understanding the health impact of head down bedrest for the benefit of older adults and astronauts. Study protocol of the Canadian Bedrest Study.Experimental physiology · 2024Article
- A novel computational framework for the estimation of internal musculoskeletal loading and muscle adaptation in hypogravity.Frontiers in physiology · 2024Article
- Optimal fibre length and maximum isometric force are the most influential parameters when modelling muscular adaptations to unloading using Hill-type muscle models.Frontiers in physiology · 2024Article
- Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration.NPJ microgravity · 2023Review
- Effect of trunk exercise upon lumbar IVD height and vertebral compliance when performed supine with 1 g at the CoM compared to upright in 1 g.BMC sports science, medicine & rehabilitation · 2022Article
- Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?Biomedicines · 2022Review
- Movement in low gravity environments (MoLo) programme-The MoLo-L.O.O.P. study protocol.PloS one · 2022Article
- Effects of 15-Days -6° Head-Down Bed Rest on the Attention Bias of Threatening Stimulus.Frontiers in psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to the spaceflight environment results in profound multi-system physiological adaptations in which there appears to be substantial inter-individual variability (IV) between crewmembers. However, performance of countermeasure exercise renders it impossible to separate the effects of the spaceflight environment
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.