ArticleFrontiers in human neuroscience2021
Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Hand Preference in Stuttering: Meta-Analyses.Neuropsychology review · 2024Pooled it
- Iron dysregulation in mice engineered with a mutation associated with stuttering.bioRxiv : the preprint server for biology · 2025Article
- An fMRI study of initiation and inhibition of manual and spoken responses in people who stutter.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dissecting structural connectivity of the left and right inferior frontal cortex in children who stutter.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Stuttering as a spectrum disorder: A hypothesis.Current research in neurobiology · 2023Review
- Brain activity during the preparation and production of spontaneous speech in children with persistent stuttering.NeuroImage. Clinical · 2023Article
- The Role of Basal Ganglia and Its Neuronal Connections in the Development of Stuttering: A Review Article.Cureus · 2022Review
- Elevated iron concentration in putamen and cortical speech motor network in developmental stuttering.Brain : a journal of neurology · 2021Article
- An unexpected iron in the fire of speech production.Brain : a journal of neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChildhood onset speech fluency disorder (stuttering) is possibly related to dopaminergic dysfunction. Mesencephalic hyperechogenicity (ME) detected by transcranial ultrasound (TCS) might be seen as an indirect marker of dopaminergic dysfunction. We here determined whether adults who stutter since childhood (AWS) show ME.
methodsWe performed TCS in ten AWS and ten matched adults who never stuttered. We also assessed motor performance in finger tapping and in the 25 Foot Walking test.
resultsCompared to controls, AWS showed enlarged ME on either side. Finger tapping was slower in AWS. Walking cadence, i.e., the ratio of number of steps by time, tended to be higher in AWS than in control participants. DISCUSSION: The results demonstrate a motor deficit in AWS linked to dopaminergic dysfunction and extending beyond speech. Since iron deposits evolve in childhood and shrink thereafter, ME might serve as an easily quantifiable biomarker helping to predict the risk of persistency in children who stutter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.