ReviewFrontiers in human neuroscience2021
The Developmental Origins of Opioid Use Disorder and Its Comorbidities.
Review in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Association of social determinants of health with opioid misuse among individuals with common psychiatric conditions.Psychiatry research communications · 2026Article
- Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents.Biological psychiatry global open science · 2025Article
- Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats.Biological psychiatry global open science · 2025Article
- Analysis and prediction of disease burden related to opioid use disorder in China based on GBD 2021.Frontiers in public health · 2025Article
- Intestinal immunoglobulins under microbial dysbiosis: implications in opioid-induced microbial dysbiosis.Frontiers in microbiology · 2025Review
- Opioid drug seeking after early-life adversity: a role for delta opioid receptors.Addiction neuroscience · 2024Article
- Evaluating a mobile app's effects on depression and anxiety in medication-treated opioid use disorder.Npj mental health research · 2024Article
- A state-level analysis of macro-level factors associated with hospital readmissions.The European journal of health economics : HEPAC : health economics in prevention and care · 2024Article
- Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- The Association Between Self-Reported Anxiety and Retention in Opioid Agonist Therapy: Findings From a Canadian Pragmatic Trial.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Childhood Traumas, Attachment Styles and Related Clinical Factors in Opioid Use Disorder.Noro psikiyatri arsivi · 2024Article
- TheFrontiers in psychology · 2024Article
- The effect of stress on opioid addiction-related behaviors: A review of preclinical literature.Experimental and clinical psychopharmacology · 2023Review
- Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development.Neuropharmacology · 2023Review
- Improving Uptake of Emergency Department-initiated Buprenorphine: Barriers and Solutions.The western journal of emergency medicine · 2022Article
- Enduring disruption of reward and stress circuit activities by early-life adversity in male rats.Translational psychiatry · 2022Article
- Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction.The European journal of neuroscience · 2022Review
- Latent trajectories of anxiety and depressive symptoms among adults in early treatment for nonmedical opioid use.Journal of affective disorders · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Opioid use disorder (OUD) rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposition, exposure to prescription opioids, and environmental risks. Crucially, one key environmental risk factor for OUD is early life adversity (ELA). OUD and other substance use disorders are widely considered to derive in part from abnormal reward circuit function, which is likely also implicated in comorbid mental illnesses such as depression, bipolar disorder, and schizophrenia. ELA may disrupt reward circuit development and function in a manner predisposing to these disorders. Here, we describe new findings addressing the effects of ELA on reward circuitry that lead to OUD and comorbid disorders, potentially
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.