Evidence map›Paper›PMID 33642997›Full record

ReviewFrontiers in cellular neuroscience2021

Kinase Signaling in Dendritic Development and Disease.

Kimya Nourbakhsh, Smita Yadav

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2025
    Article
  5. Article
  6. Review
  7. Dendritogenic Potential of the Ethanol Extract fromMolecules (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kimya NourbakhshDepartment of Pharmacology, University of Washington, Seattle, WA, United States.
Smita YadavDepartment of Pharmacology, University of Washington, Seattle, WA, United States.
University of Washington · US

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
TAOK2 Kinase Signaling in Human Neural Stem Cell DevelopmentR01MH121674 · NIMH · UNIVERSITY OF WASHINGTON · PI YADAV, SMITA · 2020 to 2024
$2.2M
Role of Autism Susceptibility Gene, TAOK2 kinase, and its novel substrates in SynaptogenesisR00MH108648 · NIMH · UNIVERSITY OF WASHINGTON · PI YADAV, SMITA · 2018 to 2020
$745k
NIGMS NIH HHS T32 GM007750NIMH NIH HHS R00 MH108648NIMH NIH HHS R01 MH121674
6 · The paper itself

Abstract

Dendrites undergo extensive growth and remodeling during their lifetime. Specification of neurites into dendrites is followed by their arborization, maturation, and functional integration into synaptic networks. Each of these distinct developmental processes is spatially and temporally controlled in an exquisite fashion. Protein kinases through their highly specific substrate phosphorylation regulate dendritic growth and plasticity. Perturbation of kinase function results in aberrant dendritic growth and synaptic function. Not surprisingly, kinase dysfunction is strongly associated with neurodevelopmental and psychiatric disorders. Herein, we review, (a) key kinase pathways that regulate dendrite structure, function and plasticity, (b) how aberrant kinase signaling contributes to dendritic dysfunction in neurological disorders and (c) emergent technologies that can be applied to dissect the role of protein kinases in dendritic structure and function.

Indexed as

dendriteskinaseskinomeneurodevelopmental diseasesneurological disorder

Identifiers

PMID33642997
PMCPMC7902504
OpenAlexW3128967248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.