ArticleFrontiers in cellular neuroscience2021
Place Cells in Head-Fixed Mice Navigating a Floating Real-World Environment.
Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tracking the Fidelity of Internal Neural Representations with Error-In-Variables Regression.bioRxiv : the preprint server for biology · 2026Article
- Ultra-wide-field, deep, adaptive two-photon microscopy for multi-scale neuronal imaging.Light, science & applications · 2026Article
- Longitudinal three-photon imaging for tracking amyloid plaques and vascular degeneration in a mouse model of Alzheimer's disease.Journal of biomedical optics · 2026Article
- Article
- The estrous cycle modulates hippocampal spine dynamics, dendritic processing, and spatial coding.Neuron · 2025Article
- All active hippocampal pyramidal cells are place cells.iScience · 2025Article
- Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Brain-wide neural recordings in mice navigating physical spaces enabled by robotic neural recording headstages.Nature methods · 2024Article
- Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment.Scientific reports · 2024Article
- Odors in space.Frontiers in neural circuits · 2024Review
- Review
- Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton.Research square · 2023Article
- An automated, low-latency environment for studying the neural basis of behavior in freely moving rats.BMC biology · 2023Article
- Neural manifold analysis of brain circuit dynamics in health and disease.Journal of computational neuroscience · 2023Review
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Article
- A Positioning Method Based on Place Cells and Head-Direction Cells for Inertial/Visual Brain-Inspired Navigation System.Sensors (Basel, Switzerland) · 2021Article
- A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampal place cell system in rodents has provided a major paradigm for the scientific investigation of memory function and dysfunction. Place cells have been observed in area CA1 of the hippocampus of both freely moving animals, and of head-fixed animals navigating in virtual reality environments. However, spatial coding in virtual reality preparations has been observed to be impaired. Here we show that the use of a real-world environment system for head-fixed mice, consisting of an air-floating track with proximal cues, provides some advantages over virtual reality systems for the study of spatial memory. We imaged the hippocampus of head-fixed mice injected with the genetically encoded calcium indicator GCaMP6s while they navigated circularly constrained or open environments on the floating platform. We observed consistent place tuning in a substantial fraction of cells despite the absence of distal visual cues. Place fields remapped when animals entered a different environment. When animals re-entered the same environment, place fields typically remapped over a time period of multiple days, faster than in freely moving preparations, but comparable with virtual reality. Spatial information rates were within the range observed in freely moving mice. Manifold analysis indicated that spatial information could be extracted from a low-dimensional subspace of the neural population dynamics. This is the first demonstration of place cells in head-fixed mice navigating on an air-lifted real-world platform, validating its use for the study of brain circuits involved in memory and affected by neurodegenerative disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.