Evidence map›Paper›PMID 33642939›Full record

ArticleInternational journal of mass spectrometry2021

Investigating native capillary zone electrophoresis-mass spectrometry on a high-end quadrupole-time-of-flight mass spectrometer for the characterization of monoclonal antibodies.

Xiaojing Shen, Zhijie Liang, Tian Xu, Zhichang Yang, Qianjie Wang, Daoyang Chen, Lucynda Pham, Wenjun Du, Liangliang Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of mass spectrometry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Capillary Electrophoresis-Mass Spectrometry for Top-Down Proteomics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2025
    Review
  6. Native Proteomics by Capillary Zone Electrophoresis-Mass Spectrometry.Angewandte Chemie (International ed. in English) · 2024
    Article
  7. Article
  8. Article
  9. To 200,000ACS central science · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Novel Strategies to Address the Challenges in Top-Down Proteomics.Journal of the American Society for Mass Spectrometry · 2021
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaojing ShenDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI, USA 48824.
Zhijie LiangDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, USA 48859.
Tian XuDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI, USA 48824.
Zhichang YangDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI, USA 48824.
Qianjie WangDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI, USA 48824.
Daoyang ChenDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI, USA 48824.
Lucynda PhamDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, USA 48859.
Wenjun DuDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, USA 48859.
Liangliang SunDepartment of Chemistry, Michigan State University, 578 S Shaw Ln, East Lansing, MI, USA 48824.

Funding

Quantitative proteomics of Zebrafish embryos and blastomeresR01GM125991 · NIGMS · MICHIGAN STATE UNIVERSITY · PI SUN, LIANGLIANG · 2018 to 2022
$1.7M
NIGMS NIH HHS R01 GM125991
6 · The paper itself

Abstract

Native capillary zone electrophoresis-mass spectrometry (CZE-MS) has attracted attentions for the characterization of monoclonal antibodies (mAbs) due to the potential of CZE for highly efficient separations of mAbs under native conditions as well as its compatibility with native electrospray ionization (ESI)-MS. However, the low sample loading capacity and limited separation resolution of native CZE for large proteins and protein complexes (

Identifiers

PMID33642939
PMCPMC7906288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.