ArticleJournal of Indian Society of Periodontology
Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Efficacy of curcumin gel as an adjunct to scaling and root planing on salivary procalcitonin level in the treatment of patients with chronic periodontitis: a randomized controlled clinical trial.BMC oral health · 2023Trial
- Measurement of procalcitonin in saliva of pigs: a pilot study.BMC veterinary research · 2022Article
- Protein and mRNA expression of interleukin-33 in periodontally diseased and healthy individuals and impact of nonsurgical periodontal therapy in salivary IL-33 levels.Journal of Indian Society of PeriodontologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProcalcitonin (ProCT) is an emerging inflammatory biomarker in bacterial infections. Few studies have reported raising salivary ProCT in periodontitis patients. Hence, the study aims to analyze and correlate the changes in saliva and serum ProCT in periodontitis patients before and after nonsurgical periodontal therapy. MATERIALS AND
methodsWe have included 15 chronic periodontitis patients of mean age 41.8 ± 6.82 years who satisfy the inclusion criteria in the study. After saliva and serum collection, clinical parameters such as plaque index, gingival index, gingival bleeding index, probing pocket depth, and clinical attachment were recorded, and scaling and root debridement were performed. Reevaluation was done at 1- and 3-month interval. ProCT was estimated using the enzyme-linked immunosorbent assay.
resultsSalivary ProCT was significantly greater than its serum counterpart at baseline and 1 month after periodontal therapy (0.20 vs. 0.26, 0.13 vs. 0.14 ng/ml respectively). We noticed a significant reduction in salivary as well as serum ProCT (35% and 46%, respectively) 1 month after scaling and root debridement. A significant moderate positive correlation was found between paired observations of salivary and serum ProCT at baseline as well as after periodontal therapy (
conclusionsSerum ProCT significantly decreases with periodontal treatment, indicating the impact of periodontal therapy on systemic inflammation. Since salivary ProCT is positively correlated with serum ProCT, we can consider it as an alternative biomarker to its serum counterpart.
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