ArticleHorticulture research2021
Genome-wide association analysis identified molecular markers associated with important tea flavor-related metabolites.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 80 citations in OpenAlex.
- Genome wide association analysis of flavour related metabolites in tea germplasm [Camellia sinensis (L.) Kuntze] from Assam using a genotyping by sequencing strategy.BMC plant biology · 2025Article
- Genomic analysis of 1,325 Camellia accessions sheds light on agronomic and metabolic traits for tea plant improvement.Nature genetics · 2025Article
- Genome-wide association study of salicylic acid provides genetic insights for tea plant selective breeding.Horticulture research · 2025Article
- Revealing novel insights into the improvement of greenhouse tea quality through exogenous substance interventions using targeted and untargeted metabolomics and microbial community analyses.Food chemistry: X · 2025Article
- Genetic diversity analysis and core germplasm construction of tea plants in Lu'an.BMC plant biology · 2025Article
- Variation analysis and quantitative trait loci mapping of 16 free amino acid traits in the tea plant (Camellia sinensis).BMC plant biology · 2025Article
- L-Theanine Metabolism in Tea Plants: Biological Functions and Stress Tolerance Mechanisms.Plants (Basel, Switzerland) · 2025Review
- Genome-wide association studies reveal potential candidate genes associated with amino acid in tea plants.PeerJ · 2025Article
- Evolution of the biochemistry underpinning purine alkaloid metabolism in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Transcriptome-Wide Association Analysis of Flavonoid Biosynthesis Genes and Their Correlation With Leaf Phenotypes in Hawk Tea (Ecology and evolution · 2024Article
- In Vitro vs. In Vivo Transcriptomic Approach Revealed Core Pathways of Nitrogen Deficiency Response in Tea Plant (International journal of molecular sciences · 2024Article
- Metabolite-based genome-wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium).Plant biotechnology journal · 2024Article
- Depicting the genetic and metabolic panorama of chemical diversity in the tea plant.Plant biotechnology journal · 2024Article
- Article
- Comprehensive dissection of variation and accumulation of free amino acids in tea accessions.Horticulture research · 2024Article
- Analysis of the Genetic Diversity in Tea Plant Germplasm in Fujian Province Based on Restriction Site-Associated DNA Sequencing.Plants (Basel, Switzerland) · 2023Article
- Genome-wide association analysis identified molecular markers and candidate genes for flower traits in Chinese orchid (Horticulture research · 2023Article
- Genome-Wide Association Studies of Biluochun Tea Plant Populations in Dongting Mountain and Comprehensive Identification of Candidate Genes Associated with Core Agronomic Traits by Four Analysis Models.Plants (Basel, Switzerland) · 2023Article
- Analysis of Functional Single-Nucleotide Polymorphisms (SNPs) and Leaf Quality in Tea Collection under Nitrogen-Deficient Conditions.International journal of molecular sciences · 2023Article
- Application of Multi-Perspectives in Tea Breeding and the Main Directions.International journal of molecular sciences · 2023Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristic secondary metabolites in tea (theanine, caffeine, and catechins) are important factors contributing to unique tea flavors. However, there has been relatively little research on molecular markers related to these metabolites. Thus, we conducted a genome-wide association analysis of the levels of these tea flavor-related metabolites in three seasons. The theanine, caffeine, and catechin levels in Population 1 comprising 191 tea plant germplasms were examined, which revealed that their heritability exceeded 0.5 in the analyzed seasons, with the following rank order (highest to lowest heritabilities): (+)-catechin > (-)-gallocatechin gallate > caffeine = (-)-epicatechin > (-)-epigallocatechin-3-gallate > theanine > (-)-epigallocatechin > (-)-epicatechin-3-gallate > catechin gallate > (+)-gallocatechin. The SNPs detected by amplified-fragment SNP and methylation sequencing divided Population 1 into three groups and seven subgroups. An association analysis yielded 307 SNP markers related to theanine, caffeine, and catechins that were common to all three seasons. Some of the markers were pleiotropic. The functional annotation of 180 key genes at the SNP loci revealed that FLS, UGT, MYB, and WD40 domain-containing proteins, as well as ATP-binding cassette transporters, may be important for catechin synthesis. KEGG and GO analyses indicated that these genes are associated with metabolic pathways and secondary metabolite biosynthesis. Moreover, in Population 2 (98 tea plant germplasm resources), 30 candidate SNPs were verified, including 17 SNPs that were significantly or extremely significantly associated with specific metabolite levels. These results will provide a foundation for future research on important flavor-related metabolites and may help accelerate the breeding of new tea varieties.
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