ArticleHorticulture research2021
Melatonin alters the secondary metabolite profile of grape berry skin by promoting VvMYB14-mediated ethylene biosynthesis.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 76 citations in OpenAlex.
- Melatonin Uncouples Ripening Promotion from Softening and Enhances the Polyphenol Profile in Postharvest 'Reineta' Apples (Plants (Basel, Switzerland) · 2026Article
- Ethylene networking in fruit ripening: molecular mechanisms, hormone crosstalk, climate interactions, and postharvest management.Plant cell reports · 2026Review
- Melatonin activates the ZjERF34-ZjMYB1 regulatory pathway to promote flavonoid biosynthesis and salt tolerance in jujube (Ziziphus jujuba Mill.).BMC plant biology · 2026Article
- Phytomelatonin in Ornamental Horticulture: A Comprehensive Review of Growth Promotion, Stress Tolerance, and Post-Harvest Quality.International journal of molecular sciences · 2026Review
- Ethylene-Mediated VvERF003 Promotes Flavonol Accumulation by UpregulatingBiomolecules · 2026Article
- Melatonin-inducedFrontiers in plant science · 2026Article
- Comparative transcriptomics of atrazine-tolerant and sensitive alfalfa varieties under atrazine stress.BMC plant biology · 2025Article
- Ethylene modulates the phenylpropanoid pathway by enhancingHorticulture research · 2025Article
- Genome-wide identification and expression analysis of ACS and ACO gene family in Ziziphus jujuba mill during fruit ripening.Scientific reports · 2025Article
- Melatonin suppresses ethylene biosynthesis by inhibiting transcription factor MdREM10 during apple fruit ripening.Horticulture research · 2025Article
- Integrated transcriptomic and metabolomic analyses reveal the mechanisms underlying bio-organic fertilizer-mediated growth and nutrient enhancement inFrontiers in plant science · 2025Article
- Integrative Metabolomic and Transcriptomic Analysis Provides Novel Insights into the Effects of SOFoods (Basel, Switzerland) · 2024Article
- Metabolite and Transcriptome Profiling Analysis Provides New Insights into the Distinctive Effects of Exogenous Melatonin on Flavonoids Biosynthesis inInternational journal of molecular sciences · 2024Article
- Article
- Nitrogen Sources Reprogram Carbon and Nitrogen Metabolism to Promote Andrographolide Biosynthesis inInternational journal of molecular sciences · 2024Article
- Appraisal of the Role of Gaseous Signaling Molecules in Thermo-Tolerance Mechanisms in Plants.Plants (Basel, Switzerland) · 2024Review
- Ethylene biosynthesis and signal transduction during ripening and softening in non-climacteric fruits: an overview.Frontiers in plant science · 2024Review
- Experimental approaches in studying active biomolecules modulating fruit ripening: Melatonin as a case study.Plant physiology · 2023Article
- Ethylene and Jasmonates Signaling Network Mediating Secondary Metabolites under Abiotic Stress.International journal of molecular sciences · 2023Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between melatonin and ethylene in the regulation of fruit metabolism and the underlying molecular mechanism of this interplay remain largely unclear. Here, widely targeted metabolomics analysis revealed a total of 464 metabolites present in berry skin. Among them, 27 significantly differentially accumulated metabolites (DAMs) were produced in response to melatonin treatment in the presence or absence of 1-MCP. Most of the DAMs were secondary metabolites, including flavonoids, phenolic acids, stilbenes, and flavonols. Additionally, the accumulation of 25 DAMs was regulated by melatonin via ethylene. RNA-seq analysis indicated that melatonin primarily regulated the pathways of plant hormone signal transduction and secondary metabolite biosynthesis via ethylene. Gene-metabolite association analysis showed that melatonin regulated the expression of the VvSTS1, VvF3H, VvLAR2, and VvDFR genes, suggesting that these genes may play key roles in regulating secondary metabolites in the skin; additionally, VvMYB14 and VvACS1 were suggested to be involved in the regulation of secondary metabolites. Further experiments revealed that melatonin induced the expression of VvMYB14 and that VvMYB14 increased ethylene production by transcriptionally activating VvACS1, thereby affecting the accumulation of secondary metabolites. Collectively, melatonin promotes ethylene biosynthesis and alters secondary metabolite accumulation through the regulation of VvACS1 by VvMYB14.
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Registered trials
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