Evidence map›Paper›PMID 33642562›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis.

Ryotaro Sakamori, Ryoko Yamada, Kazuma Shinkai, Akira Doi, Yuki Tahata, Minoru Shigekawa, Takahiro Kodama, Hayato Hikita, Tomomi Yamada, Tomohide Tatsumi and 1 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ryotaro SakamoriDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Ryoko YamadaDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Kazuma ShinkaiDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Akira DoiDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Yuki TahataDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Minoru ShigekawaDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Takahiro KodamaDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Hayato HikitaDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Tomomi YamadaDepartment of Medical Innovation, Osaka University Hospital, Japan.
Tomohide TatsumiDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Tetsuo TakeharaDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
Osaka University · JPOsaka University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) can be eliminated by direct-acting antivirals in patients with decompensated liver cirrhosis. Although viral clearance in decompensated liver cirrhosis leads to improvement of the liver function and quality of life, changes in the skeletal muscle mass after sustained virologic response (SVR) in patients with decompensated liver cirrhosis have not been reported. We present the first report of skeletal muscle mass improvement with the achievement of SVR for HCV in a 76-year-old woman with decompensated liver cirrhosis. After achieving SVR through ledipasvir/sofosbuvir treatment, the patient showed an improvement in her liver function and an increase in her skeletal muscle mass.

Indexed as

Hepatitis CHepatitis C, ChronicAgedAntiviral AgentsBenzimidazolesFemaleFluorenesHepacivirusHumansLiver CirrhosisMuscle, SkeletalQuality of LifeSofosbuvirTreatment OutcomeAntiviral AgentsBenzimidazolesFluorenesledipasvirSofosbuvirdecompensated liver cirrhosisdirect-acting antiviral (DAA)ledipasvirsarcopeniaskeletal muscle index (SMI)sofosbuvir

Identifiers

PMID33642562
PMCPMC7990635
OpenAlexW3135679180

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.