ArticleRenal failure2021
Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells.
Article in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Carbamylation is Instrumental in End-Stage Kidney Disease Coagulopathies: The Impact on von Willebrand Factor and Platelet Functionality.Thrombosis and haemostasis · 2025Article
- Antiphospholipid Antibodies Associated with Native Arteriovenous Fistula Complications in Hemodialysis Patients: A Comprehensive Review of the Literature.Antibodies (Basel, Switzerland) · 2024Review
- Thrombophilic risk factors and ABO blood group profile for arteriovenous access failure in end stage kidney disease patients: a single-center experience.Renal failure · 2022Article
- Secretory activity of the coronary artery endothelial cells in conditions of the peritoneal dialysis.Renal failure · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUremia induces various pathologic changes in the endothelium. However, there is limited information about the differences of these effects in endothelial cells originating from different parts of the vascular tree.
methodsThe effect of uremic serum obtained from patients with end stage renal failure on the gene expression and secretory activity of venous endothelial cells (VEC) and aortic endothelial cells (AEC) was studied in
resultsIn VEC, the expression of genes regulating the synthesis of von Willebrand factor (vWF) was increased by 254% (
conclusionsVEC and AEC respond in different ways after exposure to uremic serum. VEC acquires the prothrombotic phenotype, whereas in AEC the inflammatory phenotype appears.
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