ArticleThe bone & joint journal2021
The antimicrobial activity and biocompatibility of a controlled gentamicin-releasing single-layer sol-gel coating on hydroxyapatite-coated titanium.
Article in The bone & joint journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Inhibiting Effects of Antibiotic-Loaded Porous Gelatin-Hydroxyapatite Microspheres onPharmaceutics · 2025Article
- Advancements in Antimicrobial Surface Coatings Using Metal/Metaloxide Nanoparticles, Antibiotics, and Phytochemicals.Nanomaterials (Basel, Switzerland) · 2025Review
- Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition.Frontiers in bioengineering and biotechnology · 2025Article
- Effect of Gentamicin Sulfate and Polymeric Polyethylene Glycol Coating on the Degradation and Cytotoxicity of Iron-Based Biomaterials.ACS omega · 2024Article
- Advanced Antimicrobial and Anti-Infective Strategies to Manage Peri-Implant Infection: A Narrative Review.Dentistry journal · 2024Review
- Advancements in incorporating metal ions onto the surface of biomedical titanium and its alloys via micro-arc oxidation: a research review.Frontiers in chemistry · 2024Review
- [Progress in antibacterial/osteogenesis dual-functional surface modification strategy of titanium-based implants].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Review
- Adsorption Performance of Heavy Metal Ions under Multifactorial Conditions by Synthesized Organic-Inorganic Hybrid Membranes.Membranes · 2023Article
- Evaluation of bacterial attachment on mineralized collagen scaffolds and addition of manuka honey to increase mesenchymal stem cell osteogenesis.Biomaterials · 2023Article
- The Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections.Gels (Basel, Switzerland) · 2023Article
- Overview of strategies to improve the antibacterial property of dental implants.Frontiers in bioengineering and biotechnology · 2023Review
- Antibacterial Coatings for Titanium Implants: Recent Trends and Future Perspectives.Antibiotics (Basel, Switzerland) · 2022Review
- Influence of Addition of Antibiotics on Chemical and Surface Properties of Sol-Gel Coatings.Materials (Basel, Switzerland) · 2022Article
- Antimicrobial and Antibiofilm Coating of Dental Implants-Past and New Perspectives.Antibiotics (Basel, Switzerland) · 2022Review
- Vancomycin-nanofunctionalized peptide-enriched silk fibroin to prevent methicillin-resistantFrontiers in cellular and infection microbiology · 2022Article
- Long-term antibacterial properties of a nanostructured titanium alloy surface: AnMaterials today. Bio · 2022Article
- Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants.Biomedicines · 2021Review
- Antibacterial Optimization of Highly Deformed Titanium Alloys for Spinal Implants.Molecules (Basel, Switzerland) · 2021Article
- Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery.International journal of nanomedicine · 2021Review
- Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiOFrontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimsThe aim of this study was to develop a single-layer hybrid organic-inorganic sol-gel coating that is capable of a controlled antibiotic release for cementless hydroxyapatite (HA)-coated titanium orthopaedic prostheses.
methodsCoatings containing gentamicin at a concentration of 1.25% weight/volume (wt/vol), similar to that found in commercially available antibiotic-loaded bone cement, were prepared and tested in the laboratory for: kinetics of antibiotic release; activity against planktonic and biofilm bacterial cultures; biocompatibility with cultured mammalian cells; and physical bonding to the material (n = 3 in all tests). The sol-gel coatings and controls were then tested in vivo in a small animal healing model (four materials tested; n = 6 per material), and applied to the surface of commercially pure HA-coated titanium rods.
resultsThe coating released gentamicin at > 10 × minimum inhibitory concentration (MIC) for sensitive staphylococcal strains within one hour thereby potentially giving effective prophylaxis for arthroplasty surgery, and showed > 99% elution of the antibiotic within the coating after 48 hours. There was total eradication of both planktonic bacteria and established bacterial biofilms of a panel of clinically relevant staphylococci. Mesenchymal stem cells adhered to the coated surfaces and differentiated towards osteoblasts, depositing calcium and expressing the bone marker protein, osteopontin. In the in vivo small animal bone healing model, the antibiotic sol-gel coated titanium (Ti)/HA rod led to osseointegration equivalent to that of the conventional HA-coated surface.
conclusionIn this study we report a new sol-gel technology that can release gentamicin from a bioceramic-coated cementless arthroplasty material. In vitro, local gentamicin levels are in excess of what can be achieved by antibiotic-loaded bone cement. In vivo
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