Evidence map›Paper›PMID 33641386›Full record

ArticleStroke2021

Aging Immune System in Acute Ischemic Stroke: A Transcriptomic Analysis.

Gina P Sykes, Joseph Kamtchum-Tatuene, Sarina Falcione, Sarah Zehnder, Danielle Munsterman, Boryana Stamova, Bradley P Ander, Frank R Sharp, Glen Jickling

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. The age-dependent immune response to ischemic stroke.Current opinion in neurobiology · 2023
    Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Gina P SykesDivision of Neurology, Department of Medicine (G.P.S., S.Z., D.M., G.J.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Joseph Kamtchum-TatueneNeuroscience and Mental Health Institute (J.K.-T., G.J.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Sarina FalcioneDepartment of Medical Microbiology and Immunology (S.F.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Sarah ZehnderDivision of Neurology, Department of Medicine (G.P.S., S.Z., D.M., G.J.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Danielle MunstermanDivision of Neurology, Department of Medicine (G.P.S., S.Z., D.M., G.J.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Boryana StamovaDepartment of Neurology, University of California, Davis, Sacramento (B.S., B.P.A., F.R.S., G.J.).
Bradley P AnderDepartment of Neurology, University of California, Davis, Sacramento (B.S., B.P.A., F.R.S., G.J.).
Frank R SharpDepartment of Neurology, University of California, Davis, Sacramento (B.S., B.P.A., F.R.S., G.J.).
Glen JicklingDivision of Neurology, Department of Medicine (G.P.S., S.Z., D.M., G.J.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
University of Alberta · CAUniversity of California, Davis · USWomen and Children’s Health Research Institute · CA

Funding

Genomics of Intracerebral Hemorrhage and its CausesR01NS106950 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ANDER, BRADLEY PEARCE, SHARP, FRANK R · 2019 to 2023
$3.0M
Whole Genome RNA Sequencing (RNAseq) of Blood from Patients with Lacunar StrokeR01NS101718 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHARP, FRANK R, STAMOVA, BORYANA · 2017 to 2021
$3.0M
Whole Transcriptome Studies of Patients with Transient Ischemic Attacks (TIAs)R01NS097000 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHARP, FRANK R, STAMOVA, BORYANA · 2016 to 2020
$2.8M
Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid HemorrhageR61NS119345 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ANDER, BRADLEY PEARCE, SHARP, FRANK R · 2021 to 2023
$2.0M
Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid HemorrhageR33NS119345 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ANDER, BRADLEY PEARCE, SHARP, FRANK R · 2024 to 2025
$1.1M
Lipopolysaccharide Binding Protein and Lipopolysaccharide and Inflammation in Alzheimer's DiseaseR03AG069815 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHARP, FRANK R, ZHAN, XINHUA · 2021 to 2021
$314k
CIHRNIA NIH HHS R03 AG069815NINDS NIH HHS R01 NS097000NINDS NIH HHS R01 NS101718NINDS NIH HHS R01 NS106950NINDS NIH HHS R33 NS119345NINDS NIH HHS R61 NS119345
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AdultAgedAged, 80 and overAgingFemaleGene Expression ProfilingHumansImmune SystemIschemic StrokeMaleMiddle Agedagingimmune systemimmunosenescenceinflammationischemic strokeleukocytesstroke outcome

Identifiers

PMID33641386
PMCPMC8011932
OpenAlexW3134758701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.