Evidence map›Paper›PMID 33641369›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension.

Jing Wu, Shi Fang, Ko-Ting Lu, Kelsey Wackman, Michal L Schwartzman, Sergey I Dikalov, Justin L Grobe, Curt D Sigmund

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Effects of excess sodium consumption on arterial function in C57BL/6 mice.American journal of physiology. Heart and circulatory physiology · 2024
    Pooled it
  2. Current medicinal chemistry · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jing WuFrom the Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee (J.W., S.F., K.-T.L., K.W., J.L.G., C.D.S.).
Shi FangFrom the Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee (J.W., S.F., K.-T.L., K.W., J.L.G., C.D.S.).
Ko-Ting LuFrom the Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee (J.W., S.F., K.-T.L., K.W., J.L.G., C.D.S.).
Kelsey WackmanFrom the Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee (J.W., S.F., K.-T.L., K.W., J.L.G., C.D.S.).
Michal L SchwartzmanDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla (M.L.S.).
Sergey I DikalovDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (S.D.).
Justin L GrobeFrom the Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee (J.W., S.F., K.-T.L., K.W., J.L.G., C.D.S.).
Curt D SigmundFrom the Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee (J.W., S.F., K.-T.L., K.W., J.L.G., C.D.S.).
Medical College of Wisconsin · USNew York Medical College · USUniversity of Iowa · USVanderbilt University Medical Center · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2M
The Role of Inflammation in Cardiovascular DiseaseP01HL129941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNSTEIN, KENNETH E · 2016 to 2020
$12.4M
PPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial StiffnessR35HL144807 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SIGMUND, CURT DANIEL · 2019 to 2024
$5.5M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Molecular Mechanisms of 20-HETE-mediated Vascular Dysfunction and HypertensionR01HL139793 · NHLBI · NEW YORK MEDICAL COLLEGE · PI SCHWARTZMAN, MICHAL LANIADO · 2018 to 2021
$2.7M
Sirtuin 3 Inactivation and SOD2 Acetylation in Vascular Dysfunction and HypertensionR01HL157583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIKALOV, SERGEY · 2021 to 2024
$2.4M
Targeting Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionR01HL144943 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIKALOV, SERGEY · 2019 to 2022
$1.7M
Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive HypertensionK01DK126792 · NIDDK · UNIVERSITY OF ROCHESTER · PI WU, JING O. · 2021 to 2025
$721k
NHLBI NIH HHS P01 HL084207NHLBI NIH HHS P01 HL129941NHLBI NIH HHS R01 HL134850NHLBI NIH HHS R01 HL139793NHLBI NIH HHS R01 HL144943NHLBI NIH HHS R01 HL157583NHLBI NIH HHS R35 HL144807NIDDK NIH HHS K01 DK126792
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

HypertensionMuscle, Smooth, VascularAnimalsDisease Models, AnimalKidneyMiceOxidative StressPPAR gammaReceptors, Prostaglandin E, EP3 SubtypeSignal TransductionSodium ChlorideVascular ResistanceVasodilationPPAR gammaReceptors, Prostaglandin E, EP3 SubtypeSodium Chlorideblood pressurePPAR gammaprostaglandin E2sodium chloridevasodilation

Identifiers

PMID33641369
PMCPMC7946772
OpenAlexW3134135693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.