Evidence map›Paper›PMID 33641367›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

FPR-1 (Formyl Peptide Receptor-1) Activation Promotes Spontaneous, Premature Hypertension in Dahl Salt-Sensitive Rats.

Jonnelle M Edwards, Shaunak Roy, Sarah L Galla, Jeremy C Tomcho, Nicole R Bearss, Emily W Waigi, Blair Mell, Xi Cheng, Piu Saha, Matam Vijay-Kumar and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Inflammation and Resolution in Obesity-Related Cardiovascular Disease.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Regulatory effect of gut microbes on blood pressure.Animal models and experimental medicine · 2022
    Review
  12. Article
  13. Ethanol: striking the cardiovascular system by harming the gut microbiota.American journal of physiology. Heart and circulatory physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jonnelle M EdwardsFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Shaunak RoyFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Sarah L GallaFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Jeremy C TomchoFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Nicole R BearssFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Emily W WaigiFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Blair MellFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Xi ChengFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Piu SahaFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Matam Vijay-KumarFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Cameron G McCarthyFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Bina JoeFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Camilla F WenceslauFrom the Department of Pharmacology and Physiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
University of Toledo · US

Funding

Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertensionR01HL149762 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2021 to 2025
$1.9M
Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular CarcinomaR01CA219144 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI VIJAY-KUMAR, MATAM · 2017 to 2021
$1.6M
Intrarenal Arteries Sense N-formyl Peptides Leading to Vascular Injury in SepsisR00GM118885 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2019 to 2021
$746k
Autophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular agingR00HL151889 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCCARTHY, CAMERON · 2022 to 2024
$742k
Autophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular agingK99HL151889 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI MCCARTHY, CAMERON · 2020 to 2021
$220k
NCI NIH HHS R01 CA219144NHLBI NIH HHS K99 HL151889NHLBI NIH HHS R00 HL151889NHLBI NIH HHS R01 HL149762NIGMS NIH HHS R00 GM118885
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

HypertensionAnimalsBacterial Physiological PhenomenaBlood PressureCell DeathGastrointestinal MicrobiomeMitochondriaRatsRats, Inbred DahlReceptors, Formyl PeptideSodium Chloride, DietaryVascular RemodelingFpr1 protein, ratReceptors, Formyl PeptideSodium Chloride, Dietaryhypertensionmicrobiotamitochondriarats, inbred Dahlvascular remodelling

Identifiers

PMID33641367
PMCPMC7946782
OpenAlexW3135713414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.