Evidence map›Paper›PMID 33641366›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II-Induced Hypertension in PT-

Xiao Chun Li, Ana Paula Oliveira Leite, Xiaowen Zheng, Chunling Zhao, Xu Chen, Liang Zhang, Xinchun Zhou, Isabelle Rubera, Michel Tauc, Jia Long Zhuo

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The relationship between estrogen and renin angiotensin system components in the context of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review
  5. A key role of ATAmerican journal of physiology. Renal physiology · 2025
    Article
  6. Article
  7. Differential effects of deleting the angiotensin receptor ATAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  8. Article
  9. Deletion of ATAmerican journal of physiology. Renal physiology · 2024
    Article
  10. Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  11. New functions and roles of the NaPflugers Archiv : European journal of physiology · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Genetic Deletion of ATInternational journal of molecular sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiao Chun LiFrom the Tulane Hypertension and Renal Center of Excellence (X.C.L., A.P.O.L., L.Z., J.L.Z.).
Ana Paula Oliveira LeiteFrom the Tulane Hypertension and Renal Center of Excellence (X.C.L., A.P.O.L., L.Z., J.L.Z.).
Xiaowen ZhengDepartment of Emergency Medicine, Guangxi Medical University, Nanning, China (X. Zheng, C.Z.).
Chunling ZhaoDepartment of Emergency Medicine, Guangxi Medical University, Nanning, China (X. Zheng, C.Z.).
Xu ChenDepartment of Physiology (X.C.), University of Mississippi Medical Center, Jackson.
Liang ZhangFrom the Tulane Hypertension and Renal Center of Excellence (X.C.L., A.P.O.L., L.Z., J.L.Z.).
Xinchun ZhouDepartment of Pathology (X. Zhou), University of Mississippi Medical Center, Jackson.
Isabelle RuberaUniversité Côte d'Azur, CNRS UMR-7370, Laboratoire de Physiomédecine Moléculaire, Nice, France (I.R., M.T.).
Michel TaucUniversité Côte d'Azur, CNRS UMR-7370, Laboratoire de Physiomédecine Moléculaire, Nice, France (I.R., M.T.).
Jia Long ZhuoFrom the Tulane Hypertension and Renal Center of Excellence (X.C.L., A.P.O.L., L.Z., J.L.Z.).

Funding

Role of Intracrine Angiotensin II in Kidney CellsR01DK067299 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jia Long Zhuo · 2004 to 2026
$6.5M
Role of Proximal Tubule NHE3 in Angiotensin II-induced HypertensionR01DK102429 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHUO, JIA LONG · 2014 to 2021
$2.5M
Intratubular Angiotensin II and AT1a Receptors in The Proximal Tubules: Roles in Hypertension and Kidney InjuryR01DK123144 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI ZHUO, JIA LONG · 2020 to 2023
$1.8M
Novel Roles of Intracrine Angiotensin II in Proximal Tubule CellsR56DK067299 · NIDDK · HENRY FORD HEALTH SYSTEM · PI ZHUO, JIA LONG · 2009 to 2009
$352k
NIDDK NIH HHS R01 DK067299NIDDK NIH HHS R01 DK102429NIDDK NIH HHS R01 DK123144NIDDK NIH HHS R56 DK067299
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Receptor, Angiotensin, Type 1Angiotensin IIAnimalsBlood PressureDisease Models, AnimalGene Knockout TechniquesGlomerular Filtration RateHypertensionKidney Tubules, ProximalMiceNatriuresisSignal TransductionSodium-Hydrogen Exchanger 3Angiotensin IIReceptor, Angiotensin, Type 1Sodium-Hydrogen Exchanger 3angiotensin IIelectrolyteshomeostasishypertensionnatriuresis

Identifiers

PMID33641366
PMCPMC7946728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.