Trial reportHypertension (Dallas, Tex. : 1979)2021
Inorganic Nitrite Supplementation Improves Endothelial Function With Aging: Translational Evidence for Suppression of Mitochondria-Derived Oxidative Stress.
Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials.Aging clinical and experimental research · 2022Pooled it
- Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress.American journal of physiology. Heart and circulatory physiology · 2023Trial
- Effects of Fermented Garlic Extract Containing Nitric Oxide Metabolites on Blood Flow in Healthy Participants: A Randomized Controlled Trial.Nutrients · 2022Trial
- Trial
- Nitrite increases mitofusin-1 levels to inhibit vascular smooth muscle cell proliferation and prevent intimal hyperplasia.Redox biology · 2026Article
- Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long-Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab-Based Chemotherapy.Journal of the American Heart Association · 2026Article
- Nitrite supplementation alleviates cerebrovascular dysfunction in chronically stressed mice, but cognitive decline remains.Experimental physiology · 2026Article
- A Narrative Review on Nitrate-Rich Diets as Adjuncts to Antihypertensive Therapy: Enhancing Treatment Efficacy via Oxidative Stress Modulation.Biomedicines · 2025Review
- Sex-specific effects of mild kidney dysfunction on vascular function in midlife and older adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Exploring Individual Factors Affecting Endothelial Function Response Variability in Aging: Implications for Precision Nutrition.Nutrients · 2025Review
- Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women.Circulation research · 2025Article
- Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and Inflammatory Responses in Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions.The journal of cardiovascular aging · 2025Article
- Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies.The journal of cardiovascular aging · 2025Article
- Socioeconomic status as a potential mediator of arterial aging in marginalized ethnic and racial groups: current understandings and future directions.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Facilitating Nitrite-Derived S-Nitrosothiol Formation in the Upper Gastrointestinal Tract in the Therapy of Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Review
- The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy.Nutrients · 2024Review
- Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach.American journal of physiology. Heart and circulatory physiology · 2024Article
- NADNitric oxide : biology and chemistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Matthew J RossmanDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Rachel A Gioscia-RyanDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Jessica R Santos-ParkerDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Brian P ZiembaDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Kara L LubienieckiDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Lawrence C JohnsonDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Natalie E PoliektovDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Nina Z BisphamDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Kayla A WoodwardDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Erzsebet E NagyDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Nathan S BryanBaylor College of Medicine, Houston, TX (N.S.B.).
Julie A ReiszDepartment of Biochemistry and Molecular Genetics (J.A.R., A.D.), University of Colorado Anschutz Medical Campus, Aurora, CO.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics (J.A.R., A.D.), University of Colorado Anschutz Medical Campus, Aurora, CO.
Michel ChoncholDepartment of Medicine, Division of Renal Diseases and Hypertension (M.C.), University of Colorado Anschutz Medical Campus, Aurora, CO.
Amy L SindlerDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, CO (M.J.R., R.A.G.-R., J.R.S.-P., B.P.Z., K.L.L., L.C.J., N.E.P., N.Z.B., K.A.W., E.E.N., A.L.S., D.R.S.).
University of Colorado Boulder · USUniversity of Colorado Anschutz Medical Campus · USBaylor College of Medicine · US
Funding
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MUniversity of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1MSODIUM RESTRICTION &ARTERIAL COMPLIANCE IN OLDER HUMANSR01AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 1996 to 2018
$4.0MSodium Nitrite Supplementation for Improving Physiological Function in Patients with Chronic Kidney DiseaseK01DK115524 · NIDDK · UNIVERSITY OF COLORADO · PI ROSSMAN, MATTHEW J · 2018 to 2023
$1.1MMitoQ Supplementation for Improving Vascular Endothelial Function in Older AdultsF32AG053009 · NIA · UNIVERSITY OF COLORADO · PI ROSSMAN, MATTHEW J · 2016 to 2017
$107kMitochondria-targeted antioxidant therapy in age-related arterial stiffnessF31AG047784 · NIA · UNIVERSITY OF COLORADO · PI GIOSCIA-RYAN, RACHEL · 2014 to 2015
$66kNCATS NIH HHS UL1 TR002535NIA NIH HHS F31 AG047784NIA NIH HHS F32 AG053009NIA NIH HHS R01 AG013038NIA NIH HHS T32 AG000279NIDDK NIH HHS K01 DK115524
Abstract
[Figure: see text].
Indexed as
Endothelium, VascularMitochondriaSodium NitriteAgedAgingAnimalsBiomarkersDietary SupplementsDrug MonitoringFemaleHumansMetabolomicsMiceModels, AnimalOxidative StressTreatment OutcomeBiomarkersSodium Nitritemitochondrianitric oxideoxidative stressreactive oxygen speciessodium nitrite
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.