Evidence map›Paper›PMID 33641339›Full record

ArticleCirculation. Cardiovascular quality and outcomes2021

Association of Cardiac Care Regionalization With Access, Treatment, and Mortality Among Patients With ST-Segment Elevation Myocardial Infarction.

Yu-Chu Shen, Harlan Krumholz, Renee Y Hsia

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Differential benefits of cardiac care regionalization based on driving time to percutaneous coronary intervention.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 4 countries.

Yu-Chu ShenGraduate School of Defense Management, Naval Postgraduate School (Y.-C.S.).
Harlan KrumholzSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine (H.K.).
Renee Y HsiaDepartment of Emergency Medicine (R.Y.H.), University of California at San Francisco.
National Bureau of Economic Research · USUniversity of California, San Francisco · USYale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Impact of Cardiac Care Regionalization on Access, Treatment, and OutcomesR01HL134182 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Renee Yuen-Jan Hsia, YU-CHU SHEN · 2016 to 2026
$4.1M
Effects of Percutaneous Coronary Intervention Lab Openings and Closures on Patients, Hospitals, and CommunitiesR01HL114822 · NHLBI · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI HSIA, RENEE YUEN-JAN, SHEN, YU-CHU · 2012 to 2020
$2.8M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL114822NHLBI NIH HHS R01 HL134182
6 · The paper itself

Abstract

backgroundRegionalization of ST-segment elevation myocardial infarction (STEMI) systems of care has been championed over the past decade. Although timely access to percutaneous coronary intervention (PCI) has been shown to improve outcomes, no studies have determined how regionalization has affected the care and outcomes of patients. We sought to determine if STEMI regionalization is associated with changes in access, treatment, and outcomes.

methodsUsing a difference-in-differences approach, we analyzed a statewide, administrative database of 139 494 patients with STEMI in California from 2006 to 2015 using regionalization data based on a survey of all local Emergency Medical Services agencies in the state.

resultsFor patients with STEMI, the base rate of admission to a hospital with PCI capability was 72.7%, and regionalization was associated with an increase of 5.34 percentage points (95% CI, 1.58-9.10), representing a 7.1% increase. Regionalization was also associated with a statistically significant increase of 3.54 (95% CI, 0.61-6.48) percentage points in the probability of same-day PCI, representing an increase of 7.1% from the 49.7% base rate and a 4.6% relative increase (2.97 percentage points [95% CI, 0.1-5.85]) in the probability of receiving PCI at any time during the hospitalization. There was a 1.84 percentage point decrease (95% CI, -3.31 to -0.37) in the probability of receiving fibrinolytics. For 7-day mortality, regionalization was associated with a 0.53 (95% CI, -1 to -0.06) percentage point greater reduction (representing 5.8% off the base rate of 9.1%) and a 1.75 percentage point decrease in the likelihood of all-cause 30-day readmission (95% CI, -3.39 to -0.11; representing 6.4% off the base rate of 27.4%). No differences were found in longer-term mortality.

conclusionsAmong patients with STEMI in California from 2006 to 2015, STEMI regionalization was associated with increased access to a PCI-capable hospital, greater use of PCI, lower 7-day mortality, and lower 30-day readmissions.

Indexed as

Percutaneous Coronary InterventionST Elevation Myocardial InfarctionAdultAgedAged, 80 and overFemaleHumansMaleMedicareMiddle AgedThrombolytic TherapyTime FactorsTreatment OutcomeUnited Statesfibrinolysismortalitymyocardial infarctionpercutaneous coronary interventiontreatment and outcomes

Identifiers

PMID33641339
PMCPMC7969448
OpenAlexW3133656646

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.