ArticleCancer medicine2021
Racial/ethnic disparities in early-onset colorectal cancer: implications for a racial/ethnic-specific screening strategy.
Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Racial disparities in colorectal cancer clinicopathological and molecular tumor characteristics: a systematic review.Cancer causes & control : CCC · 2024Pooled it
- Dissemination of colorectal cancer information among Hispanic patients and their social network.BMC public health · 2024Trial
- Artificial Intelligence-Guided Analysis of WNT Pathway Alterations: Associations with Genomic Burden and Survival Across African American and Non-Hispanic White Populations, Age Groups, and FOLFOX Treatment in Colorectal Cancer.International journal of molecular sciences · 2026Article
- Racial/Ethnic Disparities in Early-Onset Colorectal Cancer Outcomes.Journal of racial and ethnic health disparities · 2026Article
- Disparities in Colorectal Cancer Screening and Diagnoses in the COVID Era: A Study of the VA Health System.Annals of surgical oncology · 2025Article
- Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000-2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database.Cancer medicine · 2025Article
- DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations.Clinical epigenetics · 2025Article
- Inequalities in colorectal cancer diagnosis by ethnic group: a population-level study in the English National Health Service.BMJ open gastroenterology · 2025Article
- Early-Onset Colorectal Cancer Survival by Race and Ethnicity in a Large Community-Based Insured Population.Gastro hep advances · 2025Article
- Five-year overall survival of early- and late-onset colorectal cancer in Medellín, Colombia: a comparative study.Journal of cancer research and clinical oncology · 2024Article
- Racial and Ethnic Variation in Survival in Early-Onset Colorectal Cancer.JAMA network open · 2024Article
- Effect of Medicaid Expansion in Reducing Racial Disparities in Early Onset Colorectal Cancer.Journal of racial and ethnic health disparities · 2024Article
- Early-onset cancers: Biological bases and clinical implications.Cell reports. Medicine · 2024Review
- Disparities in Colorectal Cancer Presentation at a National Cancer Institute-Designated Cancer Center and a Safety-Net Hospital during the COVID-19 Pandemic.Medical research archives · 2024Article
- Time to Endoscopy or Colonoscopy Among Adults Younger Than 50 Years With Iron-Deficiency Anemia and/or Hematochezia in the VHA.JAMA network open · 2023Article
- Impact of racial disparities and insurance status in patients with bone sarcomas in the USA : a population-based cohort study.Bone & joint research · 2022Article
- Differential Analysis of Early-Onset and Late-Onset Colorectal Cancer Based on Multidimensional Evidence Integration: A Review.Cancer control : journal of the Moffitt Cancer CenterReview
- Impact of Spanish Language Outreach on Multi-Target Stool DNA Test Adherence in a Federally Qualified Health Center in the United States.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionEarly-onset colorectal cancer (EO-CRC) is a public health concern. Starting screening at 45 years has been considered, but there is discrepancy in the recommendations. Racial disparities in EO-CRC incidence and survival are reported; however, racial/ethnic differences in EO-CRC features that could inform a racial/ethnic-tailored CRC screening strategy have not been reported. We compared features and survival among Non-Hispanic White (NHW), Non-Hispanic Black (NHB), and Hispanics with EO-CRC.
methodsCRC patients from SEER 1973-2010 database were identified, and EO-CRC was defined as CRC at <50 years. Clinical/pathological features and survival were compared between NHW, NHB, and Hispanics. Cancer-specific survival (CSS) predictors were assessed in a multivariable Cox proportional hazard model.
resultsOf 166,416 patients with CRC, 16,545 (9.9%) had EO-CRC. The EO-CRC frequencies in NHB and Hispanics were higher than NHW (12.7% vs. 16.5% vs. 8.7%, p < 0.001). EO-CRC in NHB presents more frequently in females, with well/moderately differentiated, stage IV, and is less likely to present in locations targetable by sigmoidoscopy than NHW (54.6% vs. 67.7% OR:1.7, 95% p < 0.001). 5-year CSS was lower in NHB (59.4% vs. 72.8%, HR: 1.7; 95% CI: 1.54-1.82) and Hispanics (66.4% vs. 72.8%, HR: 1.3; 95% CI: 1.16-1.39) than NHW. A regression model among patients with EO-CRC showed that being NHB or Hispanic were independent predictors for cancer-specific mortality, after adjusting for gender, grade, stage, and surgery.
conclusionEO-CRC is more likely in NHB and Hispanics. Racial disparities in clinical/pathological features and CSS between NHB and NHW/Hispanics were evidenced. A racial/ethnic specific screening strategy could be considered as an alternative for patients younger than 50 years.
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