Evidence map›Paper›PMID 33641216›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2021

A scalable computational approach to assessing response to name in toddlers with autism.

Sam Perochon, Matias Di Martino, Rachel Aiello, Jeffrey Baker, Kimberly Carpenter, Zhuoqing Chang, Scott Compton, Naomi Davis, Brian Eichner, Steven Espinosa and 12 more

Open access · greenAbstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Autism Digital Phenotyping in Preschool- and School-Age Children.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  4. Detecting Autism from Head Movements using Kinesics.Proceedings of the ... ACM International Conference on Multimodal Interaction. ICMI (Conference) · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Relationship between quantitative digital behavioral features and clinical profiles in young autistic children.Autism research : official journal of the International Society for Autism Research · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Complexity analysis of head movements in autistic toddlers.Journal of child psychology and psychiatry, and allied disciplines · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

Sam PerochonDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Matias Di MartinoDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Rachel AielloDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Jeffrey BakerDepartment of Pediatrics, Duke University, Durham, NC, USA.
Kimberly CarpenterDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Zhuoqing ChangDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Scott ComptonDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Naomi DavisDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Brian EichnerDepartment of Pediatrics, Duke University, Durham, NC, USA.
Steven EspinosaOffice of Information Technology, Duke University, Durham, NC, USA.
Jacqueline FlowersDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Lauren FranzDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Martha GaglianoDepartment of Pediatrics, Duke University, Durham, NC, USA.
Adrianne HarrisDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Jill HowardDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Scott H KollinsDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Eliana M PerrinDepartment of Pediatrics, Duke University, Durham, NC, USA.
Pradeep RajDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Marina SpanosDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Barbara WalterDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Guillermo SapiroDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Geraldine DawsonDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Duke University · USOffice of the National Coordinator for Health Information Technology · US

Funding

Recruitment and Assessment CoreP50HD093074 · NICHD · DUKE UNIVERSITY · PI SCOTT N COMPTON · 2017 to 2026
$27.6M
Novel Approaches to Infant Screening for ASD in Pediatric Primary CareR01MH121329 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE · 2019 to 2023
$3.9M
Scalable Computational Platform For Active Closed-Loop Behavioral Coding in Autism Spectrum DisorderR01MH120093 · NIMH · DUKE UNIVERSITY · PI DAWSON, GERALDINE, SAPIRO, GUILLERMO R · 2019 to 2022
$1.6M
SCH: INT: Computational Tools for Avoidaint/Restrictive Food Intake Disorder R01MH122370 · NIMH · DUKE UNIVERSITY · PI SAPIRO, GUILLERMO R, ZUCKER, NANCY L · 2019 to 2021
$860k
NICHD NIH HHS P50 HD093074NIMH NIH HHS R01 MH120093NIMH NIH HHS R01 MH121329NIMH NIH HHS R01 MH122370
6 · The paper itself

Abstract

backgroundThis study is part of a larger research program focused on developing objective, scalable tools for digital behavioral phenotyping. We evaluated whether a digital app delivered on a smartphone or tablet using computer vision analysis (CVA) can elicit and accurately measure one of the most common early autism symptoms, namely failure to respond to a name call.

methodsDuring a pediatric primary care well-child visit, 910 toddlers, 17-37 months old, were administered an app on an iPhone or iPad consisting of brief movies during which the child's name was called three times by an examiner standing behind them. Thirty-seven toddlers were subsequently diagnosed with autism spectrum disorder (ASD). Name calls and children's behavior were recorded by the camera embedded in the device, and children's head turns were coded by both CVA and a human.

resultsCVA coding of response to name was found to be comparable to human coding. Based on CVA, children with ASD responded to their name significantly less frequently than children without ASD. CVA also revealed that children with ASD who did orient to their name exhibited a longer latency before turning their head. Combining information about both the frequency and the delay in response to name improved the ability to distinguish toddlers with and without ASD.

conclusionsA digital app delivered on an iPhone or iPad in real-world settings using computer vision analysis to quantify behavior can reliably detect a key early autism symptom-failure to respond to name. Moreover, the higher resolution offered by CVA identified a delay in head turn in toddlers with ASD who did respond to their name. Digital phenotyping is a promising methodology for early assessment of ASD symptoms.

Indexed as

Autism Spectrum DisorderAutistic DisorderChildChild, PreschoolHumansInfantassessmentAutism spectrum disordersbehavioral measuresscreening.

Identifiers

PMID33641216
PMCPMC8397798
OpenAlexW3135851158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.