Evidence map›Paper›PMID 33641080›Full record

ArticleHepatology international2021

Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines.

Harshad Devarbhavi, Guruprasad Aithal, Sombat Treeprasertsuk, Hajime Takikawa, Yimin Mao, Saggere M Shasthry, Saeed Hamid, Soek Siam Tan, Cyriac Abby Philips, Jacob George and 3 more

Abstract read
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In one paragraph

Article in Hepatology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. [Chinese guideline for diagnosis and management of drug-induced liver injury (2023 version)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Guideline
  4. Trial
  5. HBV/HCV coinfection and anti-tuberculosis drug-induced liver injury: from risk assessment and exploration of mechanisms to preventive considerations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Anti-Tubercular Drug-Induced Liver Injury: Current Understanding and Emerging Directions.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  19. Article
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Harshad DevarbhaviDepartment of Gastroenterology and Hepatology, St John's Medical College Hospital, Bangalore, India. harshad.devarbhavi@gmail.com.ORCID http://orcid.org/0000-0002-3593-3746
Guruprasad AithalNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.
Sombat TreeprasertsukDepartment of Medicine, Chulalongkorn University, Bangkok, Thailand.
Hajime TakikawaFaculty of Medical Technology, Emeritus Professor, School of Medicine, Tokyo, Japan.
Yimin MaoDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, and Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Saggere M ShasthryDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Saeed HamidDepartment of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Soek Siam TanDepartment of Medicine, Hospital Selayang, Bata Caves, Selangor, Malaysia.
Cyriac Abby PhilipsThe Liver Institute, Center of Excellence in GI Sciences, Rajagiri Hospital, Aluva, Kerala, India.
Jacob GeorgeDepartment of Gastroenterology and Hepatology, Westmead Hospital and Sydney West Local Health District, Sydney, Australia.
Wasim JafriDepartment of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Shiv K SarinDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. shivsarin@gmail.com.
Asia Pacific Association of Study of Liver

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiosyncratic drug-induced liver injury mimics acute and chronic liver disease. It is under recognized and underrecognised because of the lack of pathognomonic diagnostic serological markers. Its consequences may vary from being asymptomatic to self-limiting illness to severe liver injury leading to acute liver failure. Its incidence is likely to be more common in Asia than other parts of the world, mainly because of hepatotoxicity resulting from the treatment of tuberculosis disease and the ubiquitous use of traditional and complimentary medicines in Asian countries. This APASL consensus guidelines on DILI is a concise account of the various aspects including current evidence-based information on DILI with special emphasis on DILI due to antituberculosis agents and traditional and complementary medicine use in Asia.

Indexed as

Chemical and Drug Induced Liver InjuryAsiaHumansIncidenceLiver Failure, AcuteAntituberculosis drugsAPASLConsensusDILIDrug-induced liver injuryGuidelinesHepatotoxicityMedicationsMonitoringRisk factorsTraditional and complimentary medicineTreatmentTuberculosis

Identifiers

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Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.