Evidence map›Paper›PMID 33640993›Full record

SynthesisInternational urogynecology journal2021

Interventional treatment for myofascial pelvic floor pain in women: systematic review with meta-analysis.

Claudia Pignatti Frederice, Luiz Gustavo Oliveira Brito, Glaucia Miranda Varella Pereira, Anna Lygia Barbosa Lunardi, Cássia Raquel Teatin Juliato

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urogynecology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05968937 (Baclofen in Chronic Pelvic Pain, a Randomized, Double-Blind, Placebo Controlled Trial), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05968937 phase2completednot on this mapstarted 2024, after this paper: background citation

Baclofen in Chronic Pelvic Pain, a Randomized, Double-Blind, Placebo Controlled Trial

TypeinterventionalSponsorUniversity of LouisvilleRan2024 to 2026Enrolled39ConditionsChronic Pelvic Pain SyndromeArms20 mg baclofen vaginal suppository daily per vagina, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Effects of Shatavari (International journal of women's health · 2026
    Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Claudia Pignatti FredericeDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Rua Alexander Fleming, 101, Cidade Universitária, Campinas, SP, Brazil.
Luiz Gustavo Oliveira BritoDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Rua Alexander Fleming, 101, Cidade Universitária, Campinas, SP, Brazil.ORCID http://orcid.org/0000-0002-7364-4718
Glaucia Miranda Varella PereiraDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Rua Alexander Fleming, 101, Cidade Universitária, Campinas, SP, Brazil.
Anna Lygia Barbosa LunardiDepartment of Surgery, School of Medical Sciences, University of Campinas, Campinas, Brazil.
Cássia Raquel Teatin JuliatoDepartment of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Rua Alexander Fleming, 101, Cidade Universitária, Campinas, SP, Brazil. cjuliato@unicamp.br.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/26723-5
6 · The paper itself

Abstract

introduction and hypothesisFemale myofascial pain (MFP) of the pelvic floor muscles (PFM) is a subtype of chronic pelvic pain associated with urinary, anorectal, and sexual symptoms, such as dyspareunia. Treatment remains poorly discussed, and we hypothesized that different treatments could improve outcomes versus placebo or no treatment.

methodsA systematic review (CRD 42020201419) was performed in June 2020 using the following databases: PubMed, Cochrane Library, Web of Science, Embase, Scopus, BVSalud, Clinicaltrials.gov , and PEDro, including randomized clinical trials related to MPF of PFM. Primary outcome was pain after treatment, and secondary outcomes were quality of life and sexual function. Risk of bias and quality of evidence (GRADE criteria) were evaluated. Meta-analysis for continuous variables was performed (mean difference between baseline and treatment and post-treatment mean between groups).

resultsFive studies were included (n = 218). Final mean VAS score (GRADE: very low) after 4 weeks of treatment (p = 0.14) and the mean difference from baseline and 4 weeks (p = 0.66) between groups were not different between the intervention and control groups. Quality of life according to the SF-12 questionnaire (GRADE: very low) followed the same pattern. However, sexual function (GRADE: low) according to the total FSFI score (MD = -5.07 [-8.31, -1.84], p < 0.01, i

conclusionPain and quality of life after 4 weeks of heterogeneous intervention differed between the intervention and control groups in sexual function: FSFI in studies improved in almost all domains. VAS (in three studies) and SF-12 (in two studies) failed to demonstrate differences.

Indexed as

Myofascial Pain SyndromesPelvic FloorFemaleHumansOrgasmPelvic PainQuality of LifeMeta-analysisMyofascial pain syndromePelvic floorPlaceboSystematic reviewTreatment

Identifiers

PMID33640993
OpenAlexW3135322928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.