ArticleJournal of animal science2021
Weaning causes a prolonged but transient change in immune gene expression in the intestine of piglets.
Article in Journal of animal science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 60 citations in OpenAlex.
- Gut Microbiota-Mucosal Immune Interactions Underlying Intestinal Homeostasis in Weaned Piglets.Animals : an open access journal from MDPI · 2026Review
- Chromogranin A and S100A12 protein measurement in hair of pigs: assay validation, changes across different production stages and comparison with other hair biomarkers.Veterinary research communications · 2026Article
- Effects of dietary supplementation of illite and bentonite in weaned piglets challenged withJournal of animal science and technology · 2026Article
- Mechanism of Action of Plant Extracts in Preventing Post-Weaning Diarrhea in Piglets: A Review.Veterinary sciences · 2026Review
- Weaning Influences Epithelial Morphology, Gene Expression and Gut Microbiota Composition in Piglets.Animals : an open access journal from MDPI · 2026Article
- Disruption of IgA-mediated aggregation at weaning favors mucus encroachment by commensal bacteria.NPJ biofilms and microbiomes · 2026Article
- Multi-omics integrated approach reveals host-microbiome interactions in the adaptive mechanisms of weaning piglets.Journal of animal science and technology · 2026Article
- Evaluating fecal inflammation biomarkers for non-invasive detection of weaning-related intestinal inflammation in piglets.Journal of animal science · 2026Article
- Chinese yam polysaccharide promotes jejunal development, antioxidant defense, and mucosal immunity in weaned rats.Frontiers in veterinary science · 2026Article
- Effects of nursing under the enhanced recovery after surgery concept on time to first ambulation after laparoscopic hepatectomy.World journal of gastrointestinal surgery · 2025Article
- Influence of Nutritional Strategies on Performance, Gut Barrier Function and Microbiota Composition in Weaned Piglets.Animals : an open access journal from MDPI · 2025Article
- Spray-dried porcine plasma improves piglets' performance and modulates gut immune-related genes in the first week post-weaning.Animal bioscience · 2025Article
- Microbiota-Metabolite-Host Crosstalk Mediates the Impact of Dietary Energy Levels on Colonic Homeostasis in High-Altitude Ruminants.Animals : an open access journal from MDPI · 2025Article
- A Low Dose of Berberine Is Metabolized in Weaned Piglets Without Major Changes to Gut Morphology or Gut Microbiota.Animals : an open access journal from MDPI · 2025Article
- Dietary supplementation of Galactooligosaccharides improves growth performance and intestinal barrier function of offspring.Porcine health management · 2025Article
- Evaluation of ProbioticMicroorganisms · 2025Article
- Effects of Pigs' Weaning Weight on Growth Performance and Blood Immunological, Antioxidant, and Gut Permeability Parameters in Early Nursery Period.Animals : an open access journal from MDPI · 2025Article
- Effects of monoglyceride blend on performance and intestinal health status of piglets fed diets without growth promoters.Scientific reports · 2025Article
- Effect of indigestible dietary protein on growth performance and health status of weaned pigs.Journal of animal science · 2025Article
- Manipulating early-life environment and handling alters growth trajectories, immune and stress responses, clinical indicators, and intestinal health in young pigs.Journal of animal science · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlling gut inflammation is important in managing gut disorders in the piglet after weaning. Establishing patterns of inflammation markers in the time subsequent to weaning is important for future research to determine whether interventions are effective in controlling gut inflammation. The objective of this study was to evaluate the intestinal inflammatory response during the postweaning period in piglets. A 45-d study included 108 piglets (weaned at 22 d, body weight 5.53 ± 1.19 kg), distributed in 12 pens with nine pigs per pen. Histomorphometry, gene expression of pro- and anti-inflammatory cytokines, and the quantity of immunoglobulin (Ig) A producing cells were measured in jejunum, ileum, and colon on days 0, 15, 30, and 45 postweaning. Cytokine gene expression in peripheral blood mononuclear cells and Ig quantities were analyzed in blood from piglets on days 0, 15, 30, and 45 postweaning. Histomorphometrical results showed a lower villus length directly after weaning. Results demonstrated a postweaning intestinal inflammation response for at least 15 d postweaning by upregulation of IgA producing cells and IFN-γ, IL-1α, IL-8, IL-10, IL-12α, and TGF-β in jejunum, ileum, and colon. IgM and IgA were upregulated at day 30 postweaning. IgG was downregulated at day 15 postweaning. The results indicate that weaning in piglets is associated with a prolonged and transient response in gene expression of pro- and anti-inflammatory cytokines and IgA producing cells in the intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.