Evidence map›Paper›PMID 33640716›Full record

ArticleJournal of neuroimmunology2021

Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes.

Vasiliki Pappa, Sergei Spitsin, Peter J Gaskill, Steven D Douglas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The diversity of neuroimmune circuits controlling lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Vasiliki PappaThe Children's Hospital of Philadelphia Research Institute, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA.
Sergei SpitsinThe Children's Hospital of Philadelphia Research Institute, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA.
Peter J GaskillDrexel University College of Medicine, 245 N 15th St., Philadelphia, PA 19102, USA.
Steven D DouglasThe Children's Hospital of Philadelphia Research Institute, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA. Electronic address: douglas@email.chop.edu.
Children's Hospital of Philadelphia · USDrexel University · USUniversity of Pennsylvania · US

Funding

Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube, Kelly L Jordan-Sciutto · 2013 to 2026
$23.5M
TRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6M
Project 5U01MH090325 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI BARRETT, JEFFREY SCOTT · 2009 to 2013
$5.6M
Immunoprophylaxis By Gene Transfer: Shortcut To An HIV VaccineR01AI106509 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI DOUGLAS, STEVEN DANIEL · 2013 to 2016
$4.6M
Project 3: Targeting Neurokinin 1 ReceptorP01MH105303 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI FISCHER, TRACY · 2014 to 2017
$4.3M
Mechanisms of dopamine mediated increase in HIV infection of macrophagesR01DA039005 · NIDA · DREXEL UNIVERSITY · PI GASKILL, PETER JESSE · 2015 to 2019
$1.9M
DAT-Psychostimulant mediated dopamine release increases macrophage IL-1beta production through NF-kB activation and inflammasome primingR21DA049227 · NIDA · DREXEL UNIVERSITY · PI GASKILL, PETER JESSE · 2020 to 2021
$430k
NIAID NIH HHS R01 AI106509NIAID NIH HHS T32 AI007632NIDA NIH HHS R01 DA039005NIDA NIH HHS R21 DA049227NIMH NIH HHS P01 MH105303NIMH NIH HHS P30 MH097488NIMH NIH HHS U01 MH090325
6 · The paper itself

Abstract

Neurokinin-1 receptor (NK1R) signaling can be immunomodulatory and it can lead to preferential transmigration of CD14+CD16+ monocytes across the blood brain barrier, potentially promoting the development of inflammatory neurological diseases, such as neuroHIV. To evaluate how NK1R signaling alters monocyte biology, RNA sequencing was used to define NK1R-mediated transcriptional changes in different monocyte subsets. The data show that NK1R activation induces a greater number of changes in CD14+CD16+ monocytes (152 differentially expressed genes), than in CD14+CD16- monocytes (36 genes), including increases in the expression of NF-κB and components of the NLRP3 inflammasome pathway. These results suggest that NK1R may alter the inflammatory state of CD14+CD16+ monocytes, influencing the development of neuroinflammation.

Indexed as

AdultFemaleGPI-Linked ProteinsHumansInflammationMaleMiddle AgedMonocytesReceptors, IgGReceptors, Neurokinin-1Signal TransductionTranscriptomeFCGR3B protein, humanGPI-Linked ProteinsReceptors, IgGReceptors, Neurokinin-1TACR1 protein, humanCD16Monocyte subsetsNeurokinin-1 receptorRNA sequencingSubstance P

Identifiers

PMID33640716
PMCPMC8988161
OpenAlexW3129842486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.