Evidence map›Paper›PMID 33640547›Full record

SynthesisThe Science of the total environment2021

Long-term exposure to nitrogen dioxide and mortality: A systematic review and meta-analysis.

Shiwen Huang, Haomin Li, Mingrui Wang, Yaoyao Qian, Kyle Steenland, William Michael Caudle, Yang Liu, Jeremy Sarnat, Stefania Papatheodorou, Liuhua Shi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The Science of the total environment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Catalyst-Free Selective Reduction of Nitrogen Dioxide to Nitric Oxide.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
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  7. Clearing the air: Which pollution source matters most for health?Canadian journal of public health = Revue canadienne de sante publique · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shiwen HuangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Haomin LiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Mingrui WangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Yaoyao QianGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Kyle SteenlandGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
William Michael CaudleGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Yang LiuGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Jeremy SarnatGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Stefania PapatheodorouDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Liuhua ShiGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address: liuhua.shi@emory.edu.

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
NIEHS NIH HHS P30 ES019776
6 · The paper itself

Abstract

backgroundAmbient air pollution is among the greatest environmental risks to human health. However, little is known about the health effects of nitrogen dioxide (NO

methodsWe conducted a systematic search for studies that were published up to February 2020 and performed a meta-analysis of all available epidemiologic studies evaluating the associations between long-term exposure to NO

resultsOur search initially retrieved 1349 unique studies, of which 34 studies met the inclusion criteria. The pooled hazard ratio (HR) for all-cause mortality was 1.06 (95%CI: 1.04-1.08, n = 28 studies, I

conclusionWe provide robust epidemiological evidence that long-term exposure to NO

Indexed as

Air PollutantsAir PollutionEnvironmental ExposureHumansNitrogen DioxideParticulate MatterAir PollutantsNitrogen DioxideParticulate MatterAir pollutionAll-cause mortalityCardiovascular mortalityMeta-analysisNitrogen dioxideRespiratory mortality

Identifiers

PMID33640547
PMCPMC8499020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.