SynthesisAnnals of epidemiology2021
Different biases in meta-analyses of case-control and cohort studies: an example from genomics and precision medicine.
Synthesis in Annals of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association between Telomere Length and Head and Neck Cancer Risk: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- What Is the Mechanism of Government Green Development Behavior Considering Multi-Agent Interaction? A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Associations between Metabolic Syndrome Indicators and Colon Polyps: A Mendelian Randomization Study.Endocrinology and metabolism (Seoul, Korea) · 2026Article
- Sleep Bruxism and Occlusal Function: A Case-Control Study Based on Polysomnography in Young Colombians.Journal of clinical medicine · 2025Article
- Polysomnographic and Electromyographic Evaluation of Sleep Bruxism in Young Colombian Adults: Case-Control Study.Journal of clinical medicine · 2025Article
- Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in the UK Biobank.BJPsych open · 2025Article
- MicroRNA expression alteration in chronic thromboembolic pulmonary hypertension: A systematic review.Pulmonary circulation · 2024Article
- Association between sociodemographic factors and mobility limitation among older adults: a systematic review and meta-analysis protocol.Systematic reviews · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeMeta-analyses of observational studies reduce the role of chance but also introduce bias because the individual component studies are not randomized. Further, it is plausible that the bias may be different in case-control and cohort studies. We explored these issues in meta-analyses of observational studies of Opioid Use Disorder (OUD).
methodsFrom a systematic literature review of 152 published meta-analyses, 11 fulfilled the initial inclusion criteria of observational studies of OUD. Of these, 9 were meta-analyses of case-control studies and 2 were meta-analyses of cohort studies but only 4 (3 case-control and 1 cohort) targeted more than one specific chromosomal location.
resultsThe meta-analyses of the 3 case-control studies, which included 13 individual studies, identified 12 different single nucleotide polymorphisms on 6 different genes on 5 different chromosomes. None was the same as the gene on Chromosome 15 identified from the meta-analysis of the cohort studies.
conclusionsThese data, from genetic studies, suggest biases are different in meta-analyses of case-control and cohort studies, perhaps due to greater selection bias in case-control studies. These observations have potential importance in the application of meta-analyses to many common and serious diseases, as well as genomics and precision medicine, including OUD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.