Evidence map›Paper›PMID 33640481›Full record

ArticleJournal of cardiac failure2021

Dynamic Assessment of Pulmonary Artery Pulsatility Index Provides Incremental Risk Assessment for Early Right Ventricular Failure After Left Ventricular Assist Device.

Matthew H Gonzalez, Qiuqing Wang, Dmitry M Yaranov, Chony Albert, Kathy Wolski, John Wagener, Appas Aggarwal, Venu Menon, Miriam Jacob, Wilson Tang and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cardiac failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

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  7. Foreword.Interventional cardiology (London, England) · 2024
    Article
  8. Review
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  10. Hemodynamic reserve predicts early right heart failure after LVAD implantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 2 countries.

Matthew H GonzalezHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; Department of Cardiology, Spectrum Health Medical Group, Grand Rapids, Michigan. Electronic address: mgonzalez156@gmail.com.
Qiuqing WangHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Dmitry M YaranovHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Chony AlbertHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Kathy WolskiHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
John WagenerHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Appas AggarwalHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Venu MenonHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Miriam JacobHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Wilson TangHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Eileen HsichHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
David TaylorHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Michael TongHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Edward SolteszHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Jerry D EstepHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Randall C StarlingHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Emer JoyceHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; Department of Cardiology, Mater Misericordiae University Hospital, Dublin, Ireland.
Cleveland Clinic · US

Funding

Impact of Disparities Affecting Survival among Advanced Heart Failure Patients and Transplant RecipientsR01HL141892 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HSICH, EILEEN MICHELLE, ISHWARAN, HEMANT · 2018 to 2021
$2.8M
NHLBI NIH HHS R01 HL141892
6 · The paper itself

Abstract

backgroundThe pulmonary artery pulsatility index (PAPi) has been studied to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) implantation, but only as a single time point before LVAD implantation. Multiple clinical factors and therapies impact RV function in pre-LVAD patients. Thus, we hypothesized that serial PAPi measurements during cardiac intensive care unit (CICU) optimization before LVAD implantation would provide incremental risk stratification for early RVF after LVAD implantation. METHODS AND

resultsConsecutive patients who underwent sequential pulmonary artery catherization with cardiac intensive care optimization before durable LVAD implantation were included. Serial hemodynamics were reviewed retrospectively across the optimization period. The optimal PAPi was defined by the initial PAPi + the PAPi at optimized hemodynamics. RVF was defined as need for a right ventricular assist device or prolonged inotrope use (>14 days postoperatively). Patients with early RVF had significantly lower mean optimal PAPi (3.5 vs 7.5, P < .001) compared with those who did not develop RVF. After adjusting for established risk factors of early RVF after LVAD implantation, the optimal PAPi was independently and incrementally associated with early RVF after LVAD implantation (odds ratio 0.64, 95% confidence interval 0.532-0.765, P < .0001).

conclusionsOptimal PAPi achieved during medical optimization before LVAD implantation provides independent and incremental risk stratification for early RVF, likely identifying dynamic RV reserve.

Indexed as

Heart-Assist DevicesHeart FailureVentricular Dysfunction, RightHumansPulmonary ArteryRetrospective StudiesRisk AssessmentHemodynamicsleft ventricular assist devicemechanical circulatory supportpulmonary artery catheterright ventricular failure

Identifiers

PMID33640481
PMCPMC10257976
OpenAlexW3132518333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.