ArticleProgress in neurobiology2021
Human hippocampal connectivity is stronger in olfaction than other sensory systems.
Article in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Olfactory spatial memory: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- A cognitive nose? Evaluating working memory benchmarks in the olfactory domain.Chemical senses · 2025Pooled it
- Identifying distinctive brain regions related to consumer choice behaviors on branded foods using activation likelihood estimation and machine learning.Frontiers in computational neuroscience · 2024Pooled it
- Stimulating and Recording Brain Signals in an Olfactory Context: Non-Canonical Brain Structures May Contribute to Olfactory Processing - A Case Series.Brain topography · 2026Article
- Theta oscillations are an organizational unit of odor processing in the olfactory bulb.Science advances · 2026Article
- Article
- Therapeutic Effects ofLife (Basel, Switzerland) · 2026Article
- Decoding depression: stress-derived formaldehyde initiates depressive symptoms in mouse and human.Molecular psychiatry · 2026Article
- Cycle-by-cycle respiration waveforms are coupled with the shape of neural oscillations.bioRxiv : the preprint server for biology · 2026Article
- Neuronal silence as a predictive biomarker and target for epileptic seizures suppression.Scientific reports · 2026Article
- Nasal and oral breathing modes reconfigure brain network dynamics between stabilizing integration and promoting fragmentation.Scientific reports · 2026Article
- Effect of low frequency stimulation of olfactory bulb and olfactory epithelium on epileptiform activity and synaptic plasticity following pentylenetetrazol administration in rats.Behavioral and brain functions : BBF · 2026Article
- Review
- What makes a scent trigger a memory? A cognitive decomposition of odor-evoked retrieval.iScience · 2026Article
- Olfactory processing in gifted and non-gifted children: assessing the sniffin' sticks olfactory test for threshold, discrimination, and identification abilities.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Pleasant odors specifically promote a soothing autonomic response and brain-body coupling through respiratory modulation.Scientific reports · 2025Article
- Cross-Sectional and Longitudinal Associations Between Olfaction and White-Matter Integrity Across the Lifespan.Human brain mapping · 2025Article
- Streptomyces rimosus-rich soil exposure alleviates depression-like behaviors by modulating neuroinflammation and synaptic plasticity in mice with stress.Scientific reports · 2025Article
- Using Tangible User Interfaces (TUIs): Preliminary Evidence on Memory and Comprehension Skills in Children with Autism Spectrum Disorder.Behavioral sciences (Basel, Switzerland) · 2025Article
- Corticolimbic structures activation during preparation and execution of respiratory manoeuvres in voluntary olfactory sampling: An intracranial EEG study.The Journal of physiology · 2025Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
During mammalian evolution, primate neocortex expanded, shifting hippocampal functional networks away from primary sensory cortices, towards association cortices. Reflecting this rerouting, human resting hippocampal functional networks preferentially include higher association cortices, while those in rodents retained primary sensory cortices. Research on human visual, auditory and somatosensory systems shows evidence of this rerouting. Olfaction, however, is unique among sensory systems in its relative structural conservation throughout mammalian evolution, and it is unknown whether human primary olfactory cortex was subject to the same rerouting. We combined functional neuroimaging and intracranial electrophysiology to directly compare hippocampal functional networks across human sensory systems. We show that human primary olfactory cortex-including the anterior olfactory nucleus, olfactory tubercle and piriform cortex-has stronger functional connectivity with hippocampal networks at rest, compared to other sensory systems. This suggests that unlike other sensory systems, olfactory-hippocampal connectivity may have been retained in mammalian evolution. We further show that olfactory-hippocampal connectivity oscillates with nasal breathing. Our findings suggest olfaction might provide insight into how memory and cognition depend on hippocampal interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.