Evidence map›Paper›PMID 33640348›Full record

ArticleJACC. Clinical electrophysiology2021

Area Available for Atrial Fibrillation to Propagate Is an Important Determinant of Recurrence After Ablation.

Roya Kamali, Jordan Kump, Elyar Ghafoori, Matthias Lange, Nan Hu, T Jared Bunch, Derek J Dosdall, Rob S Macleod, Ravi Ranjan

Open access · greenAbstract read
In one paragraph

Article in JACC. Clinical electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Are drivers recurring or ephemeral? observations from serial mapping of persistent atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  4. Article
  5. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  6. Article
  7. Article
  8. Ablation Lesion Assessment with MRI.Arrhythmia & electrophysiology review · 2022
    Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Roya KamaliDepartment of Bioengineering, University of Utah, Salt Lake City, Utah, USA; Cardiovascular Medicine, University of Utah, Salt Lake City, Utah, USA; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.
Jordan KumpDepartment of Orthopedic Surgery, University of New Mexico, Albuquerque, New Mexico, USA.
Elyar GhafooriDepartment of Bioengineering, University of Utah, Salt Lake City, Utah, USA; Cardiovascular Medicine, University of Utah, Salt Lake City, Utah, USA; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.
Matthias LangeNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.
Nan HuDepartment of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida, USA; Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah, USA.
T Jared BunchCardiovascular Medicine, University of Utah, Salt Lake City, Utah, USA.
Derek J DosdallNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA; Department of Surgery, University of Utah, Salt Lake City, Utah, USA.
Rob S MacleodDepartment of Bioengineering, University of Utah, Salt Lake City, Utah, USA.
Ravi RanjanDepartment of Bioengineering, University of Utah, Salt Lake City, Utah, USA; Cardiovascular Medicine, University of Utah, Salt Lake City, Utah, USA; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA. Electronic address: ravi.ranjan@hsc.utah.edu.
University of Utah · USUniversity of New Mexico · US

Funding

His-Purkinje Pacing for Low Energy Implantable Cardioverter DefibrillatorsR01HL128752 · NHLBI · UNIVERSITY OF UTAH · PI DOSDALL, DEREK J · 2015 to 2024
$5.0M
Myocardial Substrate Driven Mechanistic Insights into Atrial FibrillationR01HL142913 · NHLBI · UNIVERSITY OF UTAH · PI RANJAN, RAVI · 2018 to 2021
$2.4M
MRI-based visualization and acute targeting of gaps in atrial ablation lesionsK23HL115084 · NHLBI · UNIVERSITY OF UTAH · PI RANJAN, RAVI · 2012 to 2016
$754k
NHLBI NIH HHS K23 HL115084NHLBI NIH HHS R01 HL128752NHLBI NIH HHS R01 HL142913
6 · The paper itself

Abstract

objectivesThis study sought to evaluate atrial fibrillation (AF) ablation outcomes based on scar patterns and contiguous area available for AF wavefronts to propagate.

backgroundThe relevance of ablation scar pattern acting as a barrier for electrical propagation in recurrence after catheter ablation for persistent AF is unknown.

methodsThree-month post-ablation atrial cardiac magnetic resonance was used to determine post-ablation scar. The left atrium (LA) was divided into 5 areas based on anatomical landmarks and scar patterns. The length of gaps in scar on the area boundaries was used to calculate fibrillatory areas (FAs) by adding the weighted contribution of adjacent areas. Cylindrical as well as patient-specific computational models were used to further confirm findings.

resultsA total of 75 patients that underwent an initial ablation for AF with 2 years of follow-up were included. The average maximum FA was 7,896 ± 1,988 mm

conclusionsThis data provides mechanistic insights into AF recurrence, suggesting that post-ablation scar pattern dividing the atria into smaller regions is an important and better predictor than LA volume and total scar, with improved long-term outcomes in persistent AF.

Indexed as

Atrial FibrillationCatheter AblationHumansRecurrenceRetrospective StudiesTreatment Outcomeablationatrial fibrillationatrial mappingfibrillationmagnetic resonance imagingmechanisms of atrial fibrillation

Identifiers

PMID33640348
PMCPMC9255558
OpenAlexW3132769825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.