ArticleJournal of the American College of Radiology : JACR2021
Cardiovascular Risk in the Lung Cancer Screening Population: A Multicenter Study Evaluating the Association Between Coronary Artery Calcification and Preventive Statin Prescription.
Article in Journal of the American College of Radiology : JACR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Exploring the prevalence and clinical impact of carotid plaque burden by Doppler ultrasound in lung cancer screening participants with limited coronary artery calcification.European radiology · 2026Article
- Incidental Detection of Coronary Artery Calcification in Women Undergoing Cancer Screening or Treatment.Current atherosclerosis reports · 2026Review
- Elevated serum uric acid increases incident coronary artery calcification risk in Chinese adults undergoing health checkups.Frontiers in cardiovascular medicine · 2026Article
- Cardiovascular disease risk and Lung cancer screening for Early Assessment of Risk (project CLEAR) in Missouri: A protocol for a mixed methods study.medRxiv : the preprint server for health sciences · 2025Article
- Lung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Review
- Decreased risk of cardiovascular disease mortality associated with occasional positive screens following cancer screenings.Scientific reports · 2025Article
- Artificial intelligence in coronary artery calcium score: rationale, different approaches, and outcomes.The international journal of cardiovascular imaging · 2024Review
- Preventing ASCVD Events: Using Coronary Artery Calcification Scores to Personalize Risk and Guide Statin Therapy.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024Review
- β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers.Frontiers in pharmacology · 2024Review
- Variability in Reporting of Incidental Findings Detected on Lung Cancer Screening.Annals of the American Thoracic Society · 2023Article
- Single CT Appointment for Double Lung and Colorectal Cancer Screening: Is the Time Ripe?Diagnostics (Basel, Switzerland) · 2022Review
- Reporting Coronary Artery Calcium on Low-Dose Computed Tomography Impacts Statin Management in a Lung Cancer Screening Population.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2022Article
- Low-dose CT for lung cancer screening: position paper from the Italian college of thoracic radiology.La Radiologia medica · 2022Article
- Underreporting of Coronary Stents in LDCT for Lung Cancer Screening and Their Differentiation From Severe Coronary Artery Calcifications.Journal of computer assisted tomographyArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveCoronary artery calcification (CAC) is a marker of atherosclerotic cardiovascular disease (ASCVD), the leading cause of death in individuals receiving lung cancer screening (LCS) with low-dose CT. Our purpose was to determine the proportion of the LCS population eligible for primary ASCVD preventive statin therapy by American College of Cardiology/American Heart Association guidelines, assess statin prescription rates among statin-eligible individuals, and determine associations of CAC on downstream statin prescribing within 90 days of LCS.
methodsIndividuals receiving LCS between January 1, 2016, and December 31, 2018, across three centers were retrospectively enrolled. Statin eligibility in individuals without pre-existing ASCVD was determined by 2013 American College of Cardiology/American Heart Association guidelines: (1) low-density lipoprotein ≥190 mg/dL, (2) diabetes, or (3) ASCVD risk score ≥7.5%. CAC presence and severity (mild, moderate, heavy) were extracted from LCS reports. Variation in statin prescription rates and associations between CAC and statin prescription were determined using mixed-effects logistic regression.
resultsOf 5,495 individuals receiving LCS, 31.4% (1,724 of 5,495) had pre-existing ASCVD. Of the remaining 3,771 individuals, 73.6% were statin eligible (2,777 of 3,771). However, most lacked statin prescription (60.5%, 1,681 of 2,777). CAC was associated with downstream statin prescribing (adjusted odds ratio = 2.60, 95% confidence interval: 1.12-6.02), with a higher likelihood of statin prescribing with increasing CAC severity (adjusted odds ratio = 2.21, 95% confidence interval: 1.35-3.60).
conclusionAlthough most of the LCS population is eligible for guideline-directed statin therapy, statins are underprescribed in this group. Radiologist reporting of CAC at LCS reflects a potential opportunity to raise awareness of ASCVD risk and improve preventive statin prescribing.
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