Evidence map›Paper›PMID 33639881›Full record

Observational studyBMC nephrology2021

Age and multimorbidities as poor prognostic factors for COVID-19 in hemodialysis: a Lebanese national study.

Mabel Aoun, Rabab Khalil, Walid Mahfoud, Haytham Fatfat, Line Bou Khalil, Rashad Alameddine, Nabil Afiouni, Issam Ibrahim, Mohamad Hassan, Haytham Zarzour and 42 more

Abstract readObservational Study
In one paragraph

Observational study in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The association between stroke and COVID-19-related mortality: a systematic review and meta-analysis based on adjusted effect estimates.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Mabel AounDepartment of Nephrology, Saint-George Hospital Ajaltoun, Ajaltoun, Lebanon. aounmabel@yahoo.fr.
Rabab KhalilMakassed General Hospital, Beirut, Lebanon.
Walid MahfoudSaydet Zghorta Hospital, Zgharta, Lebanon.
Haytham FatfatMounla Hospital, Tripoli, Lebanon.
Line Bou KhalilMount-Lebanon Hospital, Hazmiyeh, Lebanon.
Rashad AlameddineOrange Nassau Hospital, Tripoli, Lebanon.
Nabil AfiouniIslamic Hospital, Tripoli, Lebanon.
Issam IbrahimYoussef Akkar Hospital, Halba, Lebanon.
Mohamad HassanDar Al-Chifae Hospital, Tripoli, Lebanon.
Haytham ZarzourZahraa Hospital, Jnah, Lebanon.
Ali JebaiBahman Hospital, Beirut, Lebanon.
Nina Mourad KhalilBahman Hospital, Beirut, Lebanon.
Luay TawilSiblin Governmental Hospital, Sebline, Lebanon.
Zeina MechrefAin Wazein Medical Village, Ain Wazein, Lebanon.
Zuhair El ImadAin Wazein Medical Village, Ain Wazein, Lebanon.
Fadia ChammaSerhal Hospital, Beirut, Lebanon.
Ayman KhalilIklim Hospital, Mazboud, Lebanon.
Sandy ZeidanCentre Hospitalier du Nord, Zghorta, Lebanon.
Balsam El GhoulCentre Hospitalier du Nord, Zghorta, Lebanon.
Georges DahdahCentre Hospitalier du Nord, Zghorta, Lebanon.
Sarah MouawadFaculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Hiba AzarFaculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Kamal Abou ChahineBeqaa Hospital, Zahlé, Lebanon.
Siba KallabAbou Jaoude Hospital, Jal el Dib, Lebanon.
Bashir MoawadAbou Jaoude Hospital, Jal el Dib, Lebanon.
Ahmad FawazLabib Hospital, Sidon, Lebanon.
Joseph HomsiKhoury Hospital, Zahle, Lebanon.
Carmen TabajaHammoud Hospital University Medical Center, Sidon, Lebanon.
Maya DelbaniHammoud Hospital University Medical Center, Sidon, Lebanon.
Rami KallabFMC Hospital, Mejdlaya, Lebanon.
Hassan HoballahSahel Hospital, Haret Hreik, Lebanon.
Wahib HaykalBeit Chabeb Hospital, Beit Chabeb, Lebanon.
Najat FaresSaint-Georges Orthodoxe Hospital, Beirut, Lebanon.
Walid RahalRahal Hospital, Akkar, Lebanon.
Wael MrouehJabal Amel Hospital, Tyre, Lebanon.
Mohammed YoussefDinnieh Hospital, Dinnieh, Lebanon.
Jamale RizkallahHaroun Hospital, Zalka, Lebanon.
Ziad SebaalyHaroun Hospital, Zalka, Lebanon.
Antoine DfouniCentre Hospitalier Universitaire Notre Dame de Secours Hospital, Byblos, Lebanon.
Norma GhosnCentre Hospitalier Universitaire Notre Dame de Secours Hospital, Byblos, Lebanon.
Nagi NawfalSacre-Coeur Hospital, Baabda, Lebanon.
Walid Abou JaoudeMiddle-East Institute of Health, Bsalim, Lebanon.
Nadine BassilMiddle-East Institute of Health, Bsalim, Lebanon.
Therese MarounMiddle-East Institute of Health, Bsalim, Lebanon.
Nabil BassilMiddle-East Institute of Health, Bsalim, Lebanon.
Chadia BeainiBellevue Medical Center, Mansourieh, Lebanon.
Boutros HaddadSaint-Georges Orthodoxe Hospital, Beirut, Lebanon.
Elie MoubarakHayek Hospital, Al Hayek, Lebanon.
Houssam RabahMakassed General Hospital, Beirut, Lebanon.
Amer AttiehYoussef Akkar Hospital, Halba, Lebanon.
Serge FinianosFaculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Dania ChelalaFaculty of Medicine, Saint-Joseph University, Beirut, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemodialysis patients with COVID-19 have been reported to be at higher risk for death than the general population. Several prognostic factors have been identified in the studies from Asian, European or American countries. This is the first national Lebanese study assessing the factors associated with SARS-CoV-2 mortality in hemodialysis patients.

methodsThis is an observational study that included all chronic hemodialysis patients in Lebanon who were tested positive for SARS-CoV-2 from 31st March to 1st November 2020. Data on demographics, comorbidities, admission to hospital and outcome were collected retrospectively from the patients' medical records. A binary logistic regression analysis was performed to assess risk factors for mortality.

resultsA total of 231 patients were included. Mean age was 61.46 ± 13.99 years with a sex ratio of 128 males to 103 females. Around half of the patients were diabetics, 79.2% presented with fever. A total of 115 patients were admitted to the hospital, 59% of them within the first day of diagnosis. Hypoxia was the major reason for hospitalization. Death rate was 23.8% after a median duration of 6 (IQR, 2 to 10) days. Adjusted regression analysis showed a higher risk for death among older patients (odds ratio = 1.038; 95% confidence interval: 1.013, 1.065), patients with heart failure (odds ratio = 4.42; 95% confidence interval: 2.06, 9.49), coronary artery disease (odds ratio = 3.27; 95% confidence interval: 1.69, 6.30), multimorbidities (odds ratio = 1.593; 95% confidence interval: 1.247, 2.036), fever (odds ratio = 6.66; 95% confidence interval: 1.94, 27.81), CRP above 100 mg/L (odds ratio = 4.76; 95% confidence interval: 1.48, 15.30), and pneumonia (odds ratio = 19.18; 95% confidence interval: 6.47, 56.83).

conclusionsThis national study identified older age, coronary artery disease, heart failure, multimorbidities, fever and pneumonia as risk factors for death in patients with COVID-19 on chronic hemodialysis. The death rate was comparable to other countries and estimated at 23.8%.

Indexed as

MultimorbidityRenal DialysisAgedAge FactorsCoronary DiseaseCOVID-19Critical CareDementiaFemaleFeverHeart FailureHospitalizationHumansLebanonMaleMiddle AgedCOVID-19HemodialysisMortalityMultimorbiditiesNational studySARS-CoV-2

Identifiers

PMID33639881
PMCPMC7912967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.