ArticleBMC neuroscience2021
Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity.
Article in BMC neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task.NeuroImage · 2022Pooled it
- Opioidergic modulation of monetary incentive delay fMRI responses.Psychopharmacology · 2025Trial
- Investigating functional connectivity differences during food vs. monetary reward processing across appetitive phenotypes of major depressive disorder.Journal of affective disorders · 2026Article
- Sex and pubertal stage as moderators of the association between resting-state connectivity of striatal circuitry and reward sensitivity in the Adolescent Brain Cognitive Development study.Developmental cognitive neuroscience · 2026Article
- Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sex differences in resting-state hypothalamic connectivity and its relationship with negative emotion and behavior measures in young adults.Brain structure & function · 2026Article
- Sex-specific neural responses to smartphone cues in young adults.Biology of sex differences · 2026Article
- Validation of the Polish adaptation of the Students' Punishment Sensitivity Scale in an educational context.Frontiers in psychology · 2026Review
- Within-person imbalance of reward sensitivity and executive functioning across adolescent development: A longitudinal examination of the dual systems model from childhood to adulthood.Developmental psychology · 2025Article
- Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- The impact of childhood trauma on short video addiction: psychological and morphological correlates.Scientific reports · 2025Article
- The incremental validity of level of personality functioning over borderline personality features in associations with early adolescent social reward processing.Personality and mental health · 2025Article
- Distinct neural computations scale the violation of expected reward and emotion in social transgressions.Communications biology · 2025Article
- Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex.Nature communications · 2024Article
- Reward processes in extinction learning and applications to exposure therapy.Journal of anxiety disorders · 2024Review
- The Relationship between Power, Sense of Power, and Cognitive Flexibility: An Analysis of Parallel Mediating Effects Based on Reward and Punishment Sensitivity.Behavioral sciences (Basel, Switzerland) · 2024Article
- Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood.Translational psychiatry · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundMen and women show differences in sensitivity to reward and punishment, which may impact behavior in health and disease. However, the neural bases of these sex differences remain under-investigated. Here, by combining functional magnetic resonance imaging (fMRI) and a variant of the Monetary Incentive Delay Task (MIDT), we examined sex differences in the neural responses to wins and losses and how individual reward and punishment sensitivity modulates these regional activities.
methodsThirty-sex men and 27 women participated in the fMRI study. We assessed sensitivity to punishment (SP) and sensitivity to reward (SR) with the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ). In the MIDT, participants pressed a button to collect reward ($1, 1¢, or nil), with the reaction time window titrated across trials so participants achieved a success rate of approximately 67%. We processed the Imaging data with published routines and evaluated the results with a corrected threshold.
resultsWomen showed higher SP score than men and men showed higher SR score than women. Men relative to women showed higher response to the receipt of dollar or cent reward in bilateral orbitofrontal and visual cortex. Men as compared to women also showed higher response to dollar loss in bilateral orbitofrontal cortex. Further, in whole-brain regressions, women relative to men demonstrated more significant modulation by SP in the neural responses to wins and larger wins, and the sex differences were confirmed by slope tests.
conclusionsTogether, men showed higher SR and neural sensitivity to both wins, large or small, and losses than women. Individual differences in SP were associated with diminished neural responses to wins and larger wins in women only. These findings highlight how men and women may differ in reward-related brain activations in the MIDT and add to the imaging literature of sex differences in cognitive and affective functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.