ArticleAsian Pacific journal of cancer prevention : APJCP2021
The Effect of Particle Size on the Cytotoxicity of Amorphous Silicon Dioxide: An in Vitro Toxicological Study.
Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Nanoparticles for antiviral nucleotide analogs: approaches and analytical challenges.Journal of virology · 2026Review
- Benchmark dose determining airborne crystalline silica particles based on A549 lung-cell line survival in an in vitro study.Scientific reports · 2024Article
- Nanoparticles and Airway Epithelial Cells: Exploring the Impacts and Methodologies in Toxicity Assessment.International journal of molecular sciences · 2024Review
- Silica nanoparticles-induced cytotoxicity and genotoxicity in A549 cell lines.Scientific reports · 2024Article
- Safety Considerations for Lyophilized Human Amniotic Membrane Impregnated with Colistin and Silver Nanoparticles.Applied biochemistry and biotechnology · 2024Article
- Airborne LTA Nanozeolites Characterization during the Manufacturing Process and External Sources Interaction with the Workplace Background.Nanomaterials (Basel, Switzerland) · 2022Article
- Mechanistic study of silica nanoparticles on the size-dependent retinal toxicity in vitro and in vivo.Journal of nanobiotechnology · 2022Article
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7 authors.
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Abstract
introductionAmorphous silicon dioxide (A-SiO2) is abundant in the Earth's crust, the A-SiO2 nano and microparticles are released into the air through industrial and manufacturing activities. Due to the limited available toxicological information, the objective of the present study was to evaluate the toxicity of different sizes of A-SiO2 particles on the A549 cell-lines in an in vitro study. MATERIALS AND
methodsThe A-SiO2 particles in two categories of nano (10-100 nm) and micro (< 5um) were used in this study. The human lung A549 cell-line was exposed to either nano- or micro-sized A-SiO2 particles at 10, 50, 100, and 250 μg/ml, and the effects were investigated.
resultsThe cytotoxicity of A-SiO2 nano and microparticles in both 24- and 72-hour exposure times resulted in decreased cell survival, mitochondrial membrane potential, and increased ROS generation which was concentration-time dependent (P <0.05) but glutathione content was not affected in a time-dependent manner. Cytotoxicity of nanoparticles, contrary to the previous study, was not higher than microparticles in the comparable dose and exposure times.
conclusionThe rate of ROS generation in the A549 cell-line exposed to A-SiO2 nanoparticles was higher than microparticles. And at the same time, cell survival for exposed cells to A-SiO2 nano and microparticles were higher for nanoparticles in shorter exposure periods and was inversely concentration- and time-dependent. Further studies on exploring the effect of size and its possible toxic mechanism are recommended to achieve a more credible risk assessment.
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