ReviewMolecular & cellular proteomics : MCP2021
Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.
Review in Molecular & cellular proteomics : MCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Protocol to measure protein half-life in cell culture using heavy water.STAR protocols · 2026Article
- Urinary metabolome dynamics inMetabolomics : Official journal of the Metabolomic Society · 2025Article
- miRNA modules for precise, tunable control of gene expression.bioRxiv : the preprint server for biology · 2025Article
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Protein Turnover Dynamics Analysis With Subcellular Spatial Resolution.Bio-protocol · 2025Article
- Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and "Protein Age".Bio-protocol · 2025Article
- Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics.PloS one · 2025Article
- Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging.Aging cell · 2025Article
- Primary Cell Culture as a Model System for Evolutionary Molecular Physiology.International journal of molecular sciences · 2024Review
- Metabolic mechanisms of species-specific developmental tempo.Developmental cell · 2024Review
- Linking mitochondria metabolism, developmental timing, and human brain evolution.Current opinion in genetics & development · 2024Review
- Epigenetic control and manipulation of neuronal maturation timing.Current opinion in genetics & development · 2024Review
- The stem cell zoo for comparative studies of developmental tempo.Current opinion in genetics & development · 2024Review
- Proteasome Activators and Ageing: Restoring Proteostasis Using Small Molecules.Sub-cellular biochemistry · 2024Review
- Distinct longevity mechanisms across and within species and their association with aging.Cell · 2023Article
- Cell time: How cells control developmental timetables.Science advances · 2023Review
- TurnoveR: A Skyline External Tool for Analysis of Protein Turnover in Metabolic Labeling Studies.Journal of proteome research · 2023Article
- Article
- Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?Biochemistry. Biokhimiia · 2022Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Cells continually degrade and replace damaged proteins. However, the high energetic demand of protein turnover generates reactive oxygen species that compromise the long-term health of the proteome. Thus, the relationship between aging, protein turnover, and energetic demand remains unclear. Here, we used a proteomic approach to measure rates of protein turnover within primary fibroblasts isolated from a number of species with diverse life spans including the longest-lived mammal, the bowhead whale. We show that organismal life span is negatively correlated with turnover rates of highly abundant proteins. In comparison with mice, cells from long-lived naked mole rats have slower rates of protein turnover, lower levels of ATP production, and reduced reactive oxygen species levels. Despite having slower rates of protein turnover, naked mole rat cells tolerate protein misfolding stress more effectively than mouse cells. We suggest that in lieu of a rapid constitutive turnover, long-lived species may have evolved more energetically efficient mechanisms for selective detection and clearance of damaged proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.