ArticleVeterinary microbiology2021
Bovine respiratory coronavirus enhances bacterial adherence by upregulating expression of cellular receptors on bovine respiratory epithelial cells.
Article in Veterinary microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Nasal shedding of bovine coronavirus during commingling is associated with reduced average daily gain and lung lesions in weaned seropositive calves.Journal of dairy science · 2026Article
- Evidence of respiratory infection by bovine coronavirus in a neonatal calf.BMC veterinary research · 2026Article
- A survey of bovine coronavirus infections in cattle with respiratory disease in Chiba Prefecture, Japan.The Journal of veterinary medical science · 2026Article
- Molecular and Clinical Study of Bovine Coronavirus andVeterinary medicine international · 2026Article
- Diagnostic Methods for Bovine Coronavirus: A Review of Recent Advancements and Challenges.Viruses · 2025Review
- Integrative transcriptomic and proteomic analyses reveal that carbon metabolism and complement system of Madin Darby Bovine Kidney cells are affected by bovine coronavirus infection.BMC veterinary research · 2025Article
- Direct TaqMan assay for the detection and genotyping of bovine viral diarrhea virus types 1 and 2.Archives of virology · 2024Article
- Bovine respiratory syncytial virus enhances the attachment of Trueperella pyogenes to cells.The Journal of veterinary medical science · 2024Article
- Pseudorabies virus infection increases the permeability of the mammalian respiratory barrier to facilitatemSphere · 2024Article
- Brain invasion of bovine coronavirus: molecular analysis of bovine coronavirus infection in calves with severe pneumonia and neurological signs.Journal of veterinary science · 2024Article
- The spatial dissimilarities and connections of the microbiota in the upper and lower respiratory tract of beef cattle.Frontiers in cellular and infection microbiology · 2023Article
- Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence.Veterinary research · 2022Review
- Survival of SARS-CoV-2 and bovine coronavirus on common surfaces of living environments.Scientific reports · 2022Article
- Advances in Bovine Coronavirus Epidemiology.Viruses · 2022Review
- Bovine Coronavirus Infects the Respiratory Tract of Cattle Challenged Intranasally.Frontiers in veterinary science · 2022Article
- Bovine Coronavirus Co-infection and Molecular Characterization in Dairy Calves With or Without Clinical Respiratory Disease.Frontiers in veterinary science · 2022Article
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine coronavirus (BCoV) is one of the agents causing bovine respiratory disease complex (BRDC), with single infection tending to be mild to moderate; the probability of developing pneumonia in BRDC may be affected by viral and bacterial combinations. Previously, we reported that bovine respiratory syncytial virus (BRSV) infection enhances adherence of Pasteurella multocida (PM) to cells derived from the bovine lower respiratory tract but that BRSV infection in cells derived from the upper respiratory tract reduces PM adherence. In this study, we sought to clarify whether the modulation of bacterial adherence to cells derived from the bovine upper and lower respiratory tract is shared by other BRDC-related viruses by infecting bovine epithelial cells from the trachea, bronchus and lung with BCoV and/or PM. The results showed that cells derived from both the upper and lower respiratory tract were susceptible to BCoV infection. Furthermore, all cells infected with BCoV exhibited increased PM adherence via upregulation of two major bacterial adhesion molecules, intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAF-R), suggesting that compared with BRSV infection, BCoV infection differentially modulates bacterial adherence. In summary, we identified distinct interaction between bovine respiratory viruses and bacterial infections.
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