Evidence map›Paper›PMID 33639346›Full record

ArticleEnvironment international2021

Ambient PM

Feiby L Nassan, Cuicui Wang, Rachel S Kelly, Jessica A Lasky-Su, Pantel S Vokonas, Petros Koutrakis, Joel D Schwartz

Abstract read
In one paragraph

Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Association of PMRespiratory research · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Prenatal Nitrogen Oxide (NOEnvironmental science & technology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Effect of PMScientific reports · 2025
    Article
  18. Article
  19. Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Article
  20. Exposure to PMEnvironmental geochemistry and health · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feiby L NassanDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: fen769@mail.harvard.edu.
Cuicui WangDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Rachel S KellyChanning Division of Network Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02129, USA.
Jessica A Lasky-SuChanning Division of Network Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02129, USA.
Pantel S VokonasVA Normative Aging Study, VA Boston Healthcare System, School of Medicine and School of Public Health, Boston University, Boston, MA 02215, USA.
Petros KoutrakisDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Joel D SchwartzDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02129, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

Funding

Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0M
Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomicsR01HL141826 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2018 to 2021
$3.4M
Multi-Omic Endotyping of AsthmaK01HL146980 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KELLY, RACHEL SABINE · 2019 to 2023
$891k
EPA R835872NHLBI NIH HHS K01 HL146980NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL141826
6 · The paper itself

Abstract

backgroundThe metabolomic signatures of short- and long-term exposure to PM

objectivesWe aimed to determine the relative contribution of the different species of PM

methodsWe performed mass-spectrometry based metabolomic profiling of plasma samples among men from the Normative Aging Study to identify metabolic pathways associated with PM

resultsBetween 2000 and 2016, 456 men provided 648 blood samples, in which 1158 metabolites were quantified. We chose 305 metabolites for the short-term and 288 metabolites for the long-term exposure in this analysis that were significantly associated (p-value < 0.01) with PM

conclusionsWe identified several significant perturbed plasma metabolites and metabolic pathways associated with exposure to PM

Indexed as

Air PollutantsAir PollutionAgedEnvironmental ExposureHumansMaleMetabolomeMetabolomicsParticulate MatterAir PollutantsParticulate MatterAir pollutionMetabolomicsParticulate matterSPECIES, Normative Aging Study (NAS)

Identifiers

PMID33639346
PMCPMC7994935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.