Evidence map›Paper›PMID 33639288›Full record

ArticleOrthopaedics & traumatology, surgery & research : OTSR2021

Absence of signature inflammatory markers in synovial fluid for total knee arthroplasties revised for arthrofibrosis.

Christopher G Salib, Nicolas Reina, Andre J van Wijnen, Arlen D Hanssen, Daniel J Berry, Matthew P Abdel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedics & traumatology, surgery & research : OTSR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. [Histopathological diagnostics of arthrofibrosis].Unfallchirurgie (Heidelberg, Germany) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christopher G SalibDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, United States.
Nicolas ReinaDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, United States.
Andre J van WijnenDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, United States.
Arlen D HanssenDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, United States.
Daniel J BerryDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, United States.
Matthew P AbdelDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, United States. Electronic address: abdel.matthew@mayo.edu.
Mayo Clinic · US

Funding

Pathologic Role of Inflammation and Mechanistic Analysis of Myofibroblastogenesis in ArthrofibrosisR01AR072597 · NIAMS · MAYO CLINIC ROCHESTER · PI ABDEL, MATTHEW P · 2018 to 2022
$1.7M
NIAMS NIH HHS R01 AR072597
6 · The paper itself

Abstract

introductionCurrent diagnostic criteria for arthrofibrosis are limited. Since many patients will be aspirated during their clinical course, synovial fluid analysis may supplement current diagnostic criteria for arthrofibrosis. The goal of this study was to determine a unique synovial fluid and inflammatory marker profile for diagnosing arthrofibrosis. HYPOTHESIS: Patients with arthrofibrosis following total knee arthroplasty will have a unique synovial fluid aspirate profile compared to control patients to aid in diagnosis. MATERIALS AND

methodsBetween 2013 and 2017, 32 patients (32 total knee arthroplasties [TKAs]) underwent revision TKAs for arthrofibrosis. Fourteen patients had pre-revision aspirations. They were 2:1 matched based on age, sex, body mass index (BMI), and year of revision to 28 patients who underwent aseptic revision TKAs for reasons other than arthrofibrosis (control group). Mean age at revision was 66years, with 64% males.

resultsIn TKAs revised for arthrofibrosis, mean total cell count was 828cells/uL. These aspirates contained a mean distribution of 46% macrophages (range: 4-76%), 31% lymphocytes (range: 11-68%), 21% neutrophils (range: 0-75%), 1% other cells (mainly synovial cells; range: 0-11%), and 1% eosinophils (range: 0-7%). There was no significant difference in mean total cell count (p=0.8) or mean distribution of macrophages (p=0.6), lymphocytes (p=0.1), neutrophils (p=0.2), eosinophils (p>0.9), or serum inflammatory markers (p>0.7) when compared to controls. All aspirations were culture negative for infection. DISCUSSION: The profile of arthrofibrotic synovial fluid aspirates and serum inflammatory marker values were similar to patients revised for non-arthrofibrotic aseptic etiologies. This suggests synovial fluid and serum inflammatory markers in non-infected knees with arthrofibrosis should expect to have characteristics similar to synovial fluid and inflammatory marker profiles in other aseptic diagnoses. LEVEL OF EVIDENCE: III; retrospective case-control study.

Indexed as

Arthroplasty, Replacement, KneeProsthesis-Related InfectionsCase-Control StudiesFemaleHumansMaleReoperationRetrospective StudiesSynovial FluidArthrofibrosisCell countDifferentialSynovial fluidTotal knee arthroplasty

Identifiers

PMID33639288
PMCPMC8087631
OpenAlexW3129674092

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Registered trials

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