Evidence map›Paper›PMID 33639204›Full record

ArticleCancer letters2021

Physical confinement during cancer cell migration triggers therapeutic resistance and cancer stem cell-like behavior.

Qionghua Shen, Tamara Hill, Xue Cai, Loan Bui, Rami Barakat, Emily Hills, Turki Almugaiteeb, Anish Babu, Patrick H Mckernan, Michelle Zalles and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Physical Forces in Glioblastoma Migration: A Systematic Review.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Qionghua ShenNeuroengineering Lab, Department of Bioengineering, University of Texas at Arlington, TX, USA.
Tamara HillNeuroengineering Lab, Department of Bioengineering, University of Texas at Arlington, TX, USA.
Xue CaiDepartment of Neurosurgery, University of Oklahoma Health Sciences Center, OK, USA.
Loan BuiDepartment of Aerospace & Mechanical Engineering, University of Notre Dame, IN, USA.
Rami BarakatNeuroengineering Lab, Department of Bioengineering, University of Texas at Arlington, TX, USA.
Emily HillsNeuroengineering Lab, Department of Bioengineering, University of Texas at Arlington, TX, USA.
Turki AlmugaiteebRPD Innovations, Riyadh, Saudi Arabia.
Anish BabuDepartment of Neurology, University of Oklahoma Health Sciences Center, OK, USA.
Patrick H MckernanDepartment of Neurology, University of Oklahoma Health Sciences Center, OK, USA.
Michelle ZallesOklahoma Medical Research Foundation, OK, USA.
James D BattisteDepartment of Neurology, University of Oklahoma Health Sciences Center, OK, USA. Electronic address: James-Battiste@ouhsc.edu.
Young-Tae KimNeuroengineering Lab, Department of Bioengineering, University of Texas at Arlington, TX, USA; Department of Urology, UT Southwestern Medical Center, TX, USA. Electronic address: ykim@uta.edu.
The University of Texas at Arlington · USUniversity of Oklahoma Health Sciences Center · USOklahoma Medical Research Foundation · USUniversity of Notre Dame · US

Funding

TUMOR RESISTANCE MECHANISMS TO ANTI-VEGF THERAPY IN PROSTATE CANCER (Sukyung Woo)P20GM103639 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HANNAFON, BETHANY · 2012 to 2022
$21.3M
NIGMS NIH HHS P20 GM103639
6 · The paper itself

Abstract

Metastasized cancer cells have an increased resistance to therapies leading to a drastic decrease in patient survival rates. However, our understanding of the cause for this enhanced resistance is lacking. In this study, we report that physically tight confinement during cancer cell migration triggers therapeutic resistance and induces cancer stem cell-like behavior including up-regulation in efflux proteins and in cancer stem cell related markers. Moreover, the re-localization of Yes-associated protein (YAP) to the cell nucleus indicated an elevated level of cytoskeletal tension. The increased cytoskeletal tension suggested that mechanical interactions between cancer cells and tight surroundings during metastasis is one of the factors that contributes to therapeutic resistance and acquisition of cancer stem cell (CSC) like features. With this system and supporting data, we are able to study cells with therapeutic resistance and CSC-like properties for the future purpose of developing new strategies for the treatment of metastatic cancer.

Indexed as

Cell Cycle ProteinsCell Line, TumorCell MovementCell ProliferationDrug Resistance, NeoplasmGlioblastomaHumansNeoplastic Stem CellsTranscription FactorsCell Cycle ProteinsTranscription FactorsYY1AP1 protein, humanCancer metastasisPhysical confinementTherapeutic resistance

Identifiers

PMID33639204
PMCPMC8112468
OpenAlexW3133112054

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.