ArticleCurrent biology : CB2021
Prefrontal cortex represents heuristics that shape choice bias and its integration into future behavior.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
- Trial-by-trial fluctuations in decision criterion shape confidence.Nature human behaviour · 2026Article
- Decoupling Choice from Motor Response Reduces Choice-History Effects.bioRxiv : the preprint server for biology · 2026Article
- Macaque Area LIP Reflects Confidence-Dependent Changes in Decision Policy.bioRxiv : the preprint server for biology · 2026Article
- History bias and its perturbation of the stimulus representation in the macaque prefrontal cortex.The Journal of physiology · 2026Article
- Accumulation of virtual tokens towards a jackpot reward enhances performance and value encoding in dorsal anterior cingulate cortex.Nature communications · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Control of cortical population activity with patterned microstimulation.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical binding of cognition to action in the human basal ganglia-thalamic circuit.bioRxiv : the preprint server for biology · 2026Article
- The geometry of context-dependent biased decisions during learning.bioRxiv : the preprint server for biology · 2026Article
- Catecholamines reduce choice history biases in perceptual decision making.PLoS biology · 2025Article
- A Bayesian hierarchical model of trial-to-trial fluctuations in decision criterion.PLoS computational biology · 2025Article
- Pre-stimulus beta power mediates explicit and implicit perceptual biases in distinct cortical areas.Communications psychology · 2025Article
- Stimulus uncertainty and relative reward rates determine adaptive responding in perceptual decision-making.PLoS computational biology · 2025Article
- Reactivation of previous decisions repulsively biases sensory encoding but attractively biases decision-making.PLoS biology · 2025Article
- Representation of a perceptual bias in the prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dopaminergic computations for perceptual decisions.Current opinion in behavioral sciences · 2024Article
- Predicting the effect of micro-stimulation on macaque prefrontal activity based on spontaneous circuit dynamics.Physical review research · 2024Article
- Complex behavior from intrinsic motivation to occupy future action-state path space.Nature communications · 2024Article
- Recurrent Neural Circuits Overcome Partial Inactivation by Compensation and Re-learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Bayesian inference is facilitated by modular neural networks with different time scales.PLoS computational biology · 2024Article
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Abstract
Goal-directed behavior requires integrating sensory information with prior knowledge about the environment. Behavioral biases that arise from these priors could increase positive outcomes when the priors match the true structure of the environment, but mismatches also happen frequently and could cause unfavorable outcomes. Biases that reduce gains and fail to vanish with training indicate fundamental suboptimalities arising from ingrained heuristics of the brain. Here, we report systematic, gain-reducing choice biases in highly trained monkeys performing a motion direction discrimination task where only the current stimulus is behaviorally relevant. The monkey's bias fluctuated at two distinct time scales: slow, spanning tens to hundreds of trials, and fast, arising from choices and outcomes of the most recent trials. Our findings enabled single trial prediction of biases, which influenced the choice especially on trials with weak stimuli. The pre-stimulus activity of neuronal ensembles in the monkey prearcuate gyrus represented these biases as an offset along the decision axis in the state space. This offset persisted throughout the stimulus viewing period, when sensory information was integrated, leading to a biased choice. The pre-stimulus representation of history-dependent bias was functionally indistinguishable from the neural representation of upcoming choice before stimulus onset, validating our model of single-trial biases and suggesting that pre-stimulus representation of choice could be fully defined by biases inferred from behavioral history. Our results indicate that the prearcuate gyrus reflects intrinsic heuristics that compute bias signals, as well as the mechanisms that integrate them into the oculomotor decision-making process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.