ArticleActa paediatrica (Oslo, Norway : 1992)2021
Maternal autoimmune disease is not associated with cancer in the offspring.
Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- Maternal autoimmune disease and offspring risk of haematological malignancies: a case-control study.EClinicalMedicine · 2024Article
- Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark.EJC paediatric oncology · 2024Article
- Article
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6 authors at 4 institutions in 3 countries.
Funding
Abstract
aimAutoimmune disease and its medication are associated with increased cancer risk in adults, but it is unknown whether maternal autoimmune disease and/or medication use in pregnancy are associated with increased cancer risk in offspring.
methodsIn this case-control study, we identified all patients under 20 years of age with their first cancer diagnosis in 1996-2014 from the Finnish Cancer Registry (n = 2029) and 1:5 population-based controls (n = 10,103) from the Medical Birth Register. We obtained information on maternal autoimmune disease and its medication from the relevant Finnish registries and used conditional logistic regression to analyse the risk of offspring cancer after maternal autoimmune disease exposure.
resultsThe odds ratio (OR) for cancer in offspring following maternal autoimmune exposure was 0.76 (95% confidence interval [CI] 0.47-1.23). Individual ORs for inflammatory bowel and connective tissue diseases were 1.08 (95% CI 0.56-2.01) and 0.50 (95% CI 0.23-1.08), respectively. The OR for maternal autoimmune medication was 0.95 (95% CI 0.80-1.14) overall and similar by drug subtype. There was an increased risk with medication in late pregnancy but the ORs were unstable owing to small numbers.
conclusionOur study does not support an increased cancer risk among offspring of women with autoimmune disease or its medication during pregnancy.
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