Evidence map›Paper›PMID 33638879›Full record

Trial reportClinical endocrinology2021

Exercise training and reproductive outcomes in women with polycystic ovary syndrome: A pilot randomized controlled trial.

Jamie L Benham, Jane E Booth, Bernard Corenblum, Steve Doucette, Christine M Friedenreich, Doreen M Rabi, Ronald J Sigal

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05603169 (Effects of High Intensity Resistance and Aerobic Training Among Women With Polycystic Ovarian Syndrome.), which is not on this map. Cited by 36 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05603169 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of High Intensity Resistance and Aerobic Training Among Women With Polycystic Ovarian Syndrome.

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2023Enrolled60ConditionsPolycystic Ovary SyndromeArmsHigh intensity resistance Exercise Training, High intensity aerobic Exercise Training
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  11. Effects of physical activity in women with polycystic ovary syndrome: a systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
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  12. Efficacy of physical activity in polycystic ovary syndrome treatment.Current opinion in endocrinology, diabetes, and obesity · 2024
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  15. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jamie L BenhamDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-2233-4613
Jane E BoothDepartment of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Bernard CorenblumDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Steve DoucetteDepartment of Community Health & Epidemiology, Dalhousie University, Halifax, NS, Canada.
Christine M FriedenreichDepartment of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Doreen M RabiDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ronald J SigalDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Funding

Cumming School of Medicine, University of Calgary/Alberta Health Services Clinical Research FundLibin Cardiovascular Institute
6 · The paper itself

Abstract

objectiveExercise is recommended for polycystic ovary syndrome (PCOS), but the most effective exercise prescription is unclear. This trial compared effects of high-intensity interval training (HIIT), continuous aerobic exercise training (CAET) and no-exercise control on reproductive, anthropometric and cardiometabolic outcomes in PCOS.

designPilot randomized controlled trial.

participantsPreviously inactive women aged 18-40 years with PCOS. MEASUREMENTS: Feasibility outcomes included recruitment, retention, adherence to exercise and daily ovulation prediction kit (OPK) testing. Preliminary efficacy outcomes included reproductive, anthropometric and cardiometabolic health markers.

resultsForty-seven women were randomized to no-exercise control (n = 17), HIIT (n = 16), or CAET (n = 14). Forty (85%) participants completed the trial. Median exercise adherence was 68% (IQR 53%, 86%). Median daily OPK-testing adherence in the first half of the intervention was 87% (IQR 61%, 97%) compared with 65% (IQR 0%, 96%) in the second half. Body mass index decreased significantly in CAET compared with control (-1.0 kg/m

conclusionsThere were feasibility challenges with adherence to daily ovulation assessment limiting the ability to analyse the effect of the exercise interventions on ovulation. CAET and HIIT were both effective at improving anthropometrics and some cardiometabolic health markers. Further studies need to determine optimal and acceptable exercise prescriptions for this population.

Indexed as

Polycystic Ovary SyndromeExerciseExercise TherapyFemaleHumansPilot ProjectsSedentary Behaviorexercisehigh-intensity interval trainingovulationovulation predictionpolycystic ovary syndromerandomized controlled trialwomen's health

Identifiers

PMID33638879
PMCPMC8360032

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.