Evidence map›Paper›PMID 33638709›Full record

SynthesisEuropean child & adolescent psychiatry2022

The association between adverse childhood experiences and common mental disorders and suicidality: an umbrella review of systematic reviews and meta-analyses.

Berhe W Sahle, Nicola J Reavley, Wenjing Li, Amy J Morgan, Marie Bee Hui Yap, Andrea Reupert, Anthony F Jorm

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European child & adolescent psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 11 pooled it
25.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 11 syntheses or guidelines pooled it, 326 citations in OpenAlex.

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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Berhe W SahleCentre for Mental Health, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Melbourne, VIC, 3010, Australia. berhe.sahle@unimelb.edu.au.ORCID http://orcid.org/0000-0003-3243-9176
Nicola J ReavleyCentre for Mental Health, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Melbourne, VIC, 3010, Australia.
Wenjing LiCentre for Mental Health, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Melbourne, VIC, 3010, Australia.
Amy J MorganCentre for Mental Health, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Melbourne, VIC, 3010, Australia.
Marie Bee Hui YapCentre for Mental Health, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Melbourne, VIC, 3010, Australia.
Andrea ReupertFaculty of Education, Monash University, Melbourne, VIC, Australia.
Anthony F JormCentre for Mental Health, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Melbourne, VIC, 3010, Australia.
The University of Melbourne · AUMonash University · AU

Funding

NEUROBEHAVIORAL ADAPTATIONS, HORMONES, AND STRESSF32MH011534 · NIMH · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SCHIML, PATRICIA A · 1996 to 1998
–
The National Health and Medical Research Council (NHMRC) and Beyond Blue co-funded Centre of Research Excellence in Childhood Adversity and Mental Health (#1153419). 1153419
6 · The paper itself

Abstract

Adverse childhood experiences (ACEs) are related to increased risk of common mental disorders. This umbrella review of systematic reviews and meta-analyses aimed to identify the key ACEs that are consistently associated with increased risk of mental disorders and suicidality. We searched PsycINFO, PubMed, and Google Scholar for systematic reviews and meta-analyses on the association between ACEs and common mental disorders or suicidality published from January 1, 2009 until July 11, 2019. The methodological quality of included reviews was evaluated using the AMSTAR2 checklist. The effect sizes reported in each meta-analysis were combined using a random-effects model. Meta-regressions were conducted to investigate whether associations vary by gender or age of exposure to ACEs. This review is registered with PROSPERO (CRD42019146431). We included 68 reviews with moderate (55%), low (28%) or critically low (17%) methodological quality. The median number of included studies in these reviews was 14 (2-277). Across identified reviews, 24 ACEs were associated with increased risk of common mental disorders or suicidality. ACEs were associated with a two-fold higher odds of anxiety disorders (pooled odds ratios (ORs): 1.94; 95% CI 1.82, 2.22), internalizing disorders (OR 1.76; 1.59, 1.87), depression (OR 2.01; 1.86, 2.32) and suicidality (OR 2.33; 2.11, 2.56). These associations did not significantly (P > 0.05) vary by gender or the age of exposure. ACEs are consistently associated with increased risk of common mental disorders and suicidality. Well-designed cohort studies to track the impact of ACEs, and trials of interventions to prevent them or reduce their impact should be global research priorities.

Indexed as

Adverse Childhood ExperiencesMental DisordersSuicideHumansMeta-Analysis as TopicSystematic Reviews as TopicAdverse childhood experiencesEvidence synthesisMental healthSuicideUmbrella review

Identifiers

PMID33638709
OpenAlexW3132603698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.