Evidence map›Paper›PMID 33638689›Full record

ArticleEuropean journal of applied physiology2021

Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals-a pilot study.

Aaron L Slusher, Brandon G Fico, Katelyn M Dodge, Ryan S Garten, Peter J Ferrandi, Alexandra A Rodriguez, Gabriel Pena, Chun-Jung Huang

Erratum issuedAbstract read
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In one paragraph

Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Aaron L SlusherSchool of Kinesiology, University of Michigan, Ann Arbor, MI, 48109, USA. alslush@umich.edu.ORCID http://orcid.org/0000-0003-2082-4827
Brandon G FicoDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, 78712, USA.
Katelyn M DodgeExercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Ryan S GartenDepartment of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Peter J FerrandiCollege of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Alexandra A RodriguezExercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Gabriel PenaDepartment of Kinesiology, University of Maryland-College Park, College Park, MD, 20742, USA.
Chun-Jung HuangExercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Florida Atlantic University · USThe University of Texas at Austin · USUniversity of Maryland, College Park · USUniversity of Michigan · USUniversity of Tennessee Health Science Center · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePentraxin 3 (PTX3) has been shown to be a predictor of endothelial dysfunction in patients with increased risk of cardiovascular disease (CVD) (e.g., obesity). Circulating PTX3 concentrations are dysregulated in obese individuals and are elevated following acute aerobic exercise. High-intensity interval exercise (HIIE) has been demonstrated to be as effective as continuous moderate-intensity exercise in improving endothelial function, as indicated by brachial artery flow-mediated dilation (BAFMD), in patients with CVD. Therefore, the purpose of this study was to examine the effect of acute HIIE on plasma PTX3 and BAFMD responses in obese individuals.

methodsEight obese and six normal-weight young males participated in acute HIIE (4 intervals of 4 min at 80-90% of VO

resultsPlasma PTX3 concentrations significantly increased following HIIE, yet the PTX3 response to HIIE was significantly blunted in obese compared to normal-weight participants. While the kinetic responses of BAFMD were also significantly different in obese compared to normal-weight participants, similar increases above the baseline were observed 2 hours into recovery in both groups. Finally, plasma PTX3 concentrations were not associated with BAFMD at baseline or in response to HIIE.

conclusionThe utilization of HIIE may serve as a time-efficient exercise prescription strategy to transiently improve endothelial function, independent of elevated plasma PTX3 concentrations, in obese individuals.

Indexed as

High-Intensity Interval TrainingBrachial ArteryC-Reactive ProteinEndothelium, VascularHumansMaleObesityPentraxinsPilot ProjectsSerum Amyloid P-ComponentYoung AdultC-Reactive ProteinPentraxinsSerum Amyloid P-ComponentBrachial artery flow-mediated dilationEndothelial functionHigh-intensity interval exerciseObesityPentraxin 3

Identifiers

PMID33638689
OpenAlexW3131055335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.