Evidence map›Paper›PMID 33638300›Full record

ArticleBipolar disorders2021

Perceived helpfulness of bipolar disorder treatment: Findings from the World Health Organization World Mental Health Surveys.

Andrew A Nierenberg, Meredith G Harris, Alan E Kazdin, Victor Puac-Polanco, Nancy Sampson, Daniel V Vigo, Wai Tat Chiu, Hannah N Ziobrowski, Jordi Alonso, Yasmin Altwaijri and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Andrew A NierenbergDauten Family Center for Bipolar Treatment Innovation, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2897-0458
Meredith G HarrisSchool of Public Health, The University of Queensland, Herston, QLD, Australia.
Alan E KazdinDepartment of Psychology, Yale University, New Haven, CT, USA.
Victor Puac-PolancoDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6024-6542
Nancy SampsonDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Daniel V VigoDepartment of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Wai Tat ChiuDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Hannah N ZiobrowskiDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Jordi AlonsoHealth Services Research Unit, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
Yasmin AltwaijriEpidemiology Section, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Guilherme BorgesNational Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico.
Brendan BuntingSchool of Psychology, Ulster University, Londonderry, United Kingdom.
José Miguel Caldas-de-AlmeidaLisbon Institute of Global Mental Health and Chronic Diseases Research Center (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
Josep Maria HaroParc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
Chi-Yi HuShenzhen Institute of Mental Health & Shenzhen Kangning Hospital, Shenzhen, China.
Andrzej KiejnaPsychology Research Unit for Public Health, WSB University, Torun, Poland.
Sing LeeDepartment of Psychiatry, Chinese University of Hong Kong, Tai Po, Hong Kong.
John J McGrathNational Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
Fernando Navarro-MateuUDIF-SM, Servicio Murciano de Salud, Murcia, Spain.
José Posada-VillaFaculty of Social Sciences, Colegio Mayor de Cundinamarca University, Bogota, Colombia.
Kate M ScottDepartment of Psychological Medicine, University of Otago, Dunedin, Otago, New Zealand.
Juan C StagnaroDepartamento de Psiquiatría y Salud Mental, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Maria C VianaDepartment of Social Medicine, Postgraduate Program in Public Health, Federal University of Espírito Santo, Vitoria, Brazil.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4831-2305
WHO World Mental Health Survey Collaborators

Funding

EPIDEMIOLOGY-- NATIONAL COMORBIDITY SURVEY REPLICATIONU01MH060220 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 1999 to 2010
$18.7M
Risk Factors for Psychopathology in the WHO WMH SurveysR01MH070884 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 2005 to 2009
$6.0M
Social Role Disability and Mental-Physical Co-MorbidityR01MH069864 · NIMH · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI VON KORFF, MICHAEL R · 2004 to 2007
$2.2M
CROSS-NATIONAL STUDIES OF DRUG INVOLVEMENT: WMH2000R01DA016558 · NIDA · MICHIGAN STATE UNIVERSITY · PI ANTHONY, JAMES CHRISTOPHER · 2003 to 2008
$1.7M
World Mental Health Consortium Annual Meeting 2003-07R13MH066849 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEERINGA, STEVEN G · 2003 to 2007
$735k
Lebanon-Epidemiology: The NCS Replication StudyR03TW006481 · FIC · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 2004 to 2006
$142k
FIC NIH HHS R03 TW006481NIDA NIH HHS R01 DA016558NIMH NIH HHS R01 MH069864NIMH NIH HHS R01 MH070884NIMH NIH HHS R13 MH066849NIMH NIH HHS U01 MH060220
6 · The paper itself

Abstract

objectivesTo examine patterns and predictors of perceived treatment helpfulness for mania/hypomania and associated depression in the WHO World Mental Health Surveys.

methodsFace-to-face interviews with community samples across 15 countries found n = 2,178 who received lifetime mania/hypomania treatment and n = 624 with lifetime mania/hypomania who received lifetime major depression treatment. These respondents were asked whether treatment was ever helpful and, if so, the number of professionals seen before receiving helpful treatment. Patterns and predictors of treatment helpfulness were examined separately for mania/hypomania and depression.

results63.1% (mania/hypomania) and 65.1% (depression) of patients reported ever receiving helpful treatment. However, only 24.5-22.5% were helped by the first professional seen, which means that the others needed to persist in help seeking after initial unhelpful treatments in order to find helpful treatment. Projections find only 22.9% (mania/hypomania) and 43.3% (depression) would persist through a series of unhelpful treatments but that the proportion helped would increase substantially if persistence increased. Few patient-level significant predictors of helpful treatment emerged and none consistently either across the two components (i.e., provider-level helpfulness and persistence after earlier unhelpful treatment) or for both mania/hypomania and depression. Although prevalence of treatment was higher in high-income than low/middle-income countries, proportional helpfulness among treated cases was nearly identical in the two groups of countries.

conclusionsProbability of patients with mania/hypomania and associated depression obtaining helpful treatment might increase substantially if persistence in help-seeking increased after initially unhelpful treatments, although this could require seeing numerous additional treatment providers. In addition to investigating reasons for initial treatments not being helpful, messages reinforcing the importance of persistence should be emphasized to patients.

Indexed as

Bipolar DisorderMajor Depressive DisorderHealth SurveysHumansSurveys and QuestionnairesWorld Health Organizationbipolar disorderpatient-reported outcomestreatment effectiveness

Identifiers

PMID33638300
PMCPMC8387507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.