Evidence map›Paper›PMID 33638252›Full record

ArticleBipolar disorders2021

Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?

Jan Scott, Jacob J Crouse, Nicholas Ho, Joanne Carpenter, Nicholas Martin, Sarah Medland, Richard Parker, Enda Byrne, Baptiste Couvy-Duchesne, Brittany Mitchell and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The effect of sleep-wake behaviors on the onset of mania in youth: A computational model.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  4. Addressing the unmet needs of bipolar disorder in Australia and beyond.The Australian and New Zealand journal of psychiatry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Jan ScottBrain and Mind Centre, The University of Sydney, Sydney, Australia.ORCID 0000-0002-7203-8601
Jacob J CrouseBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Nicholas HoBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Joanne CarpenterBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Nicholas MartinQIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Sarah MedlandQIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Richard ParkerQIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Enda ByrneInstitute of Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Baptiste Couvy-DuchesneQIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Brittany MitchellQIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Kathleen MerikangasGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Ian HickieBrain and Mind Centre, The University of Sydney, Sydney, Australia.
The University of Sydney · AUQIMR Berghofer Medical Research Institute · AUThe University of Queensland · AUInstitut national de recherche en sciences et technologies du numérique · FRNational Institute of Mental Health · USQueensland University of Technology · AUVirginia Commonwealth University · US

Funding

Population-Based Epidemiologic ResearchZIAMH002953 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2016 to 2025
$7.0M
Genetic & environmental pathways to drug use, abuse & dependenceR00DA023549 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI GILLESPIE, NATHAN ALEXANDER · 2010 to 2012
$717k
NIDA NIH HHS R00 DA023549
6 · The paper itself

Abstract

objectivesNetwork analysis is increasingly applied to psychopathology research. We used it to examine the core phenomenology of emerging bipolar disorder (BD I and II) and 'at risk' presentations (major depression with a family history of BD). METHODOLOGY: The study sample comprised a community cohort of 1867 twin and nontwin siblings (57% female; mean age ~26) who had completed self-report ratings of (i) depression-like, hypomanic-like and psychotic-like experiences; (ii) family history of BD; and (iii) were assessed for mood and psychotic syndromes using the Composite International Diagnostic Interview (CIDI). Symptom networks were compared for recent onset BD versus other cohort members and then for individuals at risk of BD (depression with/without a family history of BD).

resultsThe four key symptoms that differentiated recent onset BD from other cohort members were: anergia, psychomotor speed, hypersomnia and (less) loss of confidence. The four key symptoms that differentiated individuals at high risk of BD from unipolar depression were anergia, psychomotor speed, impaired concentration and hopelessness. However, the latter network was less stable and more error prone.

conclusionsWe are encouraged by the overlaps between our findings and those from two recent publications reporting network analyses of BD psychopathology, especially as the studies recruited from different populations and employed different network models. However, the advantages of applying network analysis to youth mental health cohorts (which include many individuals with multimorbidity) must be weighed against the disadvantages including basic issues such as judgements regarding the selection of items for inclusion in network models.

Indexed as

Bipolar DisorderMajor Depressive DisorderMental DisordersAdolescentFemaleHumansMalePsychopathologySelf ReportYoung Adultactivationbipolar disordernetwork analysisrisk factorssleep-wake cycle

Identifiers

PMID33638252
PMCPMC8387492
OpenAlexW3132340593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.