ArticleHuman brain mapping2021
Vascular origins of low-frequency oscillations in the cerebrospinal fluid signal in resting-state fMRI: Interpretation using photoplethysmography.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Age-Related Low Frequency Amplitude Differences in Resting-State Blood Oxygenation Level-Dependent Signal in the Cerebellum.Human brain mapping · 2026Article
- Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system.Frontiers in physiology · 2026Article
- Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons.Annals of medicine · 2025Review
- Association between low-frequency oscillations in blood pressure variability and brain age derived from neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Assessing the feasibility of a new approach to measure the full spectrum of cerebrospinal fluid dynamics within the human brain using MRI: insights from a simulation study.Interface focus · 2025Article
- Epidural pressure measurement using a fiber-optic sensor (proof-of-principle in vivo animal trial).Animal models and experimental medicine · 2024Article
- Comparing data-driven physiological denoising approaches for resting-state fMRI: implications for the study of aging.Frontiers in neuroscience · 2024Article
- Cardiovascular and vasomotor pulsations in the brain and periphery during awake and NREM sleep in a multimodal fMRI study.Frontiers in neuroscience · 2024Article
- Characterizing systemic physiological effects on the blood oxygen level dependent signal of resting-state fMRI in time-frequency space using wavelets.Human brain mapping · 2023Article
- Article
- Cerebrovascular activity is a major factor in the cerebrospinal fluid flow dynamics.NeuroImage · 2022Article
- Resting-state functional magnetic resonance imaging signal variations in aging: The role of neural activity.Human brain mapping · 2022Article
- Real-Time Phase-Contrast MRI to Monitor Cervical Blood and Cerebrospinal Fluid Flow Beat-by-Beat Variability.Biosensors · 2022Article
- Spatial analysis of photoplethysmography in cutaneous squamous cell carcinoma.Scientific reports · 2022Article
- Increased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy.Communications medicine · 2022Article
- Vascular origins of low-frequency oscillations in the cerebrospinal fluid signal in resting-state fMRI: Interpretation using photoplethysmography.Human brain mapping · 2021Article
- The Role of Cerebrovascular-Reactivity Mapping in Functional MRI: Calibrated fMRI and Resting-State fMRI.Frontiers in physiology · 2021Review
- Effect of Various Lengths of Respiration on Heart Rate Variability during Simple Bhramari (Humming).International journal of yogaArticle
- Choroid plexus vascular reactivity in moyamoya: Implications for choroid plexus regulation in ischemic stress.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In vivo mapping of cerebrovascular oscillations in the 0.05-0.15 Hz remains difficult. Oscillations in the cerebrospinal fluid (CSF) represent a possible avenue for noninvasively tracking these oscillations using resting-state functional MRI (rs-fMRI), and have been used to correct for vascular oscillations in rs-fMRI functional connectivity. However, the relationship between low-frequency CSF and vascular oscillations remains unclear. In this study, we investigate this relationship using fast simultaneous rs-fMRI and photoplethysmogram (PPG), examining the 0.1 Hz PPG signal, heart-rate variability (HRV), pulse-intensity ratio (PIR), and the second derivative of the PPG (SDPPG). The main findings of this study are: (a) signals in different CSF regions are not equivalent in their associations with vascular and tissue rs-fMRI signals; (b) the PPG signal is maximally coherent with the arterial and CSF signals at the cardiac frequency, but coherent with brain tissue at ~0.2 Hz; (c) PIR is maximally coherent with the CSF signal near 0.03 Hz; and (d) PPG-related vascular oscillations only contribute to ~15% of the CSF (and arterial) signal in rs-fMRI. These findings caution against averaging all CSF regions when extracting physiological nuisance regressors in rs-fMRI applications, and indicate the drivers of the CSF signal are more than simply cardiac. Our study is an initial attempt at the refinement and standardization of how the CSF signal in rs-fMRI can be used and interpreted. It also paves the way for using rs-fMRI in the CSF as a potential tool for tracking cerebrovascular health through, for instance, the potential relationship between PIR and the CSF signal.
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