ArticlePhytochemical analysis : PCA2021
A supercritical fluid workflow for the quality assessment of herbal drugs and commercial preparations from Rhodiola rosea.
Article in Phytochemical analysis : PCA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Adulteration prevention-oriented systematic review of chemical constituents in the genusFrontiers in pharmacology · 2026Review
- Development of Orally Disintegrating Tablets of StandardizedPharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Ultra High-Performance Supercritical Fluid Chromatography for the Quantitation of Diterpene Resin Acids in Norway Spruce Samples.Frontiers in pharmacology · 2022Article
- A supercritical fluid workflow for the quality assessment of herbal drugs and commercial preparations from Rhodiola rosea.Phytochemical analysis : PCA · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionPreparations from the Rhodiola rosea are experiencing an increase in popularity: extracts of dried roots and rhizomes are used as adaptogen to treat stress, fatigue, and weakness. To meet high pharmaceutical standards, fast and reliable methods to assess phytochemical variations in respect of quality control are needed.
objectiveThe aim of this study was to extract and quantify seven characteristic secondary metabolites of R. rosea, namely p-tyrosol (1), rosin (2), rosiridin (3), salidroside (4), rosarin (5), rosavin (6), and tricin-5-O-β-d-glucopyranoside (7) in 24 herbal drugs and seven commercial preparations using a newly established supercritical fluid workflow.
methodsThe developed protocol allowed for an exhaustive extraction of compounds 1-7 using 60% carbon dioxide (CO
resultsThe seven compounds were separated in a remarkably short time (< 3.5 minutes). For their quantitation, good results in terms of selectivity, linearity (R
conclusionThe quantitative analysis of the investigated herbal drugs showed a highly differing metabolite pattern which was also observed in the investigated commercial products. None of the commercial dietary products met the declared content of rosavins and salidroside. The developed and validated protocol offers a novel and reliable method to assess the quantitative composition of Rhodiola herbal drugs and preparations.
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