ArticleJournal of veterinary internal medicine2021
Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- HS-GC/MS-Based Targeted Blood VOC Panel for Canine Cancer Screening Using an Integrated Classification Framework in Retrospective Korea and Thailand Cohorts.International journal of molecular sciences · 2026Article
- Multiple Modelling Methods Suggest That Grain-Free Diets Are Not Predictive of New Owner-Reported Cardiac Diagnoses Over Two Years in the Dog Aging Project, Despite Owner Misclassification of Diet.Veterinary medicine and science · 2026Article
- Role of Diet as a Predisposing Factor for Dilated Cardiomyopathy in Dogs: A Narrative Review.Veterinary sciences · 2025Review
- Grain-Free Diets for Dogs and Cats: An Updated Review Focusing on Nutritional Effects and Health Considerations.Animals : an open access journal from MDPI · 2025Review
- Transthoracic echocardiographic reference intervals in 214 adult Golden retrievers.The Journal of veterinary medical science · 2025Article
- Different carbohydrate sources in dog foods supported overall health and cardiac function: an 18-mo prospective study in healthy adult dogs.Journal of animal science · 2025Article
- Quantitative bile acid profiling in healthy adult dogs and pups from serum, plasma, urine, and feces using LC-MS/MS.Frontiers in veterinary science · 2024Article
- Domestic dogs maintain clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year.PloS one · 2024Article
- The effect of taurine supplementation on the renin-angiotensin-aldosterone system of dogs with congestive heart failure.Scientific reports · 2023Article
- Comparison of echocardiography, biomarkers and taurine concentrations in cats eating high- or low-pulse diets.Journal of feline medicine and surgery · 2023Article
- Article
- Influence of sex on renin-angiotensin-aldosterone system metabolites and enzymes in Doberman Pinschers.Journal of veterinary internal medicine · 2023Article
- Comparison of echocardiographic measurements and cardiac biomarkers in healthy dogs eating nontraditional or traditional diets.Journal of veterinary internal medicine · 2023Article
- Article
- Oligosaccharides and diet-related dilated cardiomyopathy in beagles.Frontiers in veterinary science · 2023Article
- Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls.Scientific reports · 2022Article
- Preliminary Data on Echocardiographic Evaluation and Serum Taurine Concentration in Healthy Dogs of Two Breeds (10 Golden Retrievers and 12 German Shorthaired Pointers) with Different Predispositions to Nutritional Dilated Cardiomyopathy: A Pilot Study.Animals : an open access journal from MDPI · 2022Article
- Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities.Journal of veterinary internal medicine · 2022Article
- Responses in randomised groups of healthy, adult Labrador retrievers fed grain-free diets with high legume inclusion for 30 days display commonalities with dogs with suspected dilated cardiomyopathy.BMC veterinary research · 2022Article
- Prospective study of dilated cardiomyopathy in dogs eating nontraditional or traditional diets and in dogs with subclinical cardiac abnormalities.Journal of veterinary internal medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssociations of diet with dilated cardiomyopathy are under investigation.
objectivesThat cardiac assessment would show abnormalities in healthy dogs eating grain-free (GF) diets or diets with Food and Drug Administration (FDA)-listed ingredients of concern (peas, lentils, or potatoes) as top 10 ingredients (FDA-PLP), but not in dogs eating grain-inclusive (GI) diets or diets without FDA-listed ingredients of concern (PLP) in the top 10 ingredients (NoFDA-PLP). ANIMALS: One hundred eighty-eight healthy Doberman Pinschers, Golden Retrievers, Miniature Schnauzers, and Whippets.
methodsThis study was an observational cross-sectional study. Echocardiograms, cardiac biomarkers, and blood and plasma taurine concentrations were compared between dogs eating GF (n = 26) and GI (n = 162) diets, and between FDA-PLP (n = 39) and NoFDA-PLP (n = 149) diets, controlling for age and breed. Demographic characteristics, murmurs, genetic status, and ventricular premature complexes (VPCs) during examination were compared between dogs eating different diet types.
resultsNo differences in echocardiographic variables, N-terminal pro-B-type natriuretic peptide or whole blood taurine were noted between dogs eating different diet types. Dogs eating GF diets had higher median high-sensitivity cardiac troponin I (hs-cTnI) (GF 0.076 ng/mL [Interquartile range (IQR), 0.028-0.156] vs. GI 0.048 [IQR, 0.0026-0.080]; P < .001) and higher median plasma taurine (GF 125 nmol/mL [IQR, 101-148] vs GI 104 [IQR, 86-123]; P = .02) than dogs eating GI diets. Dogs eating FDA-PLP diets had higher median hs-cTnI (0.059 ng/mL [IQR, 0.028-0.122]) than dogs eating NoFDA-PLP diets (0.048 [IQR, 0.025-0.085]; P = .006). A greater proportion of dogs eating FDA-PLP diets (10%) had VPCs than dogs eating NoFDA-PLP diets (2%; P = .04). CONCLUSIONS AND CLINICAL IMPORTANCE: Higher hs-cTnI in healthy dogs eating GF and FDA-PLP diets might indicate low-level cardiomyocyte injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.